Alam Mariam, Lewis William, Harp Joanna, Steele Katherine, Rosenbach Misha, Micheletti Robert G
Drs. Alam, Lewis, Steele, Rosenbach, and Micheletti are from the Department of Dermatology, University of Pennsylvania, Philadelphia. Dr. Harp is from New York-Presbyterian/Weill Cornell Medical Center, New York.
Cutis. 2021 Apr;107(4):209-215. doi: 10.12788/cutis.0230.
Cutaneous manifestations of COVID-19-SARS-CoV-2-are common and varied. Morbilliform, vesicular, and urticarial eruptions may be nonspecific initial features of the disease. Chilblainlike lesions on the fingers or toes typically occur as part of a resolution phase, signifying a milder course, whereas livedoid lesions and retiform purpura are associated with coaguloapthy and more severe disease. Additionally, a severe Kawasaki-like multisystem inflammatory syndrome rarely is seen in children. This diverse range of cutaneous manifestations in COVID-19 reflects a spectrum of host immunologic responses to SARS-CoV-2 and may inform disease pathophysiology.
新型冠状病毒肺炎(COVID-19,即严重急性呼吸综合征冠状病毒2[SARS-CoV-2]感染)的皮肤表现常见且多样。斑丘疹、水疱及荨麻疹样皮疹可能是该病的非特异性初始特征。手指或脚趾上的冻疮样病变通常出现在病情缓解期,意味着病程较轻,而类生活状皮病和网状紫癜则与凝血异常及更严重的疾病相关。此外,儿童中罕见严重的川崎病样多系统炎症综合征。COVID-19中这种多样的皮肤表现反映了宿主对SARS-CoV-2的一系列免疫反应,可能为疾病的病理生理学提供线索。