Layton Shannon S, Polancich Shea, Schexnayder Julie, Noot Ross Vander, Bogie Kath, Patrician Patricia
School of Nursing, University of Alabama at Birmingham, Birmingham, Alabama, USA.
School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Int Wound J. 2025 Apr;22(4):e70193. doi: 10.1111/iwj.70193.
This study describes characteristics and factors associated with cutaneous manifestations of COVID-19 encountered across acute inpatient, and critical care units in a large Southeastern USA public hospital from March 1, 2020, through November 01, 2021. A retrospective descriptive analysis was conducted on a purposive sample of patients consulted for non-pressure injury related cutaneous wounds while positive for COVID-19. Patients were predominantly male (64.3%, n = 27), White (66.7%, n = 28) and Black (33.3%). No cutaneous wounds while positive for COVID-19 were observed for Hispanic patients. Patient mortality was 71.4% (n = 30). Gender distribution was proportionate by gender (67% were male) and race (65.5% were White) for deceased patients. Body mass index (BMI) ranged from 15.8 to 61.2 with a mean of 31.9 (SD = 10.76) and median BMI 28.7. Identification of cutaneous manifestations of COVID-19 and understanding of the retiform purpura pathophysiology could prove useful in guiding COVID-19 treatment regimens. Investigation into factors preventing complement cascading in those of Hispanic ethnicity may be useful in the prevention of CMC-19 and progression of severity of illness.
本研究描述了2020年3月1日至2021年11月1日期间，在美国东南部一家大型公立医院的急性住院部和重症监护病房中遇到的与新冠病毒病皮肤表现相关的特征和因素。对因非压力性损伤相关皮肤伤口而就诊且新冠病毒检测呈阳性的患者进行了回顾性描述性分析。患者以男性为主（64.3%，n = 27），白人（66.7%，n = 28）和黑人（33.3%）。未观察到西班牙裔患者有新冠病毒检测呈阳性时的皮肤伤口。患者死亡率为71.4%（n = 30）。死亡患者的性别分布按性别（67%为男性）和种族（65.5%为白人）成比例。体重指数（BMI）范围为15.8至61.2，平均为31.9（标准差 = 10.76），BMI中位数为28.7。识别新冠病毒病的皮肤表现并了解网状紫癜的病理生理学可能有助于指导新冠病毒病的治疗方案。对西班牙裔人群中阻止补体级联反应的因素进行调查，可能有助于预防新冠病毒病相关的补体介导的微血管病变（CMC-19）和疾病严重程度的进展。
