Watsky M A, Jablonski M M, Edelhauser H F
Medical College of Wisconsin, Department of Physiology, Milwaukee 53226.
Curr Eye Res. 1988 May;7(5):483-6. doi: 10.3109/02713688809031801.
This comparative study shows the surface area ratio of conjunctiva to cornea to be two times larger in humans than in rabbits. This large heretofore unrecognized interspecies difference may affect the applicability of drug pharmacokinetic data obtained using rabbit models and should be taken into consideration in topical drug development and future comparative drug penetration studies between rabbit and man.
这项比较研究表明，人类结膜与角膜的表面积比是兔子的两倍。这种迄今为止未被认识到的种间差异可能会影响使用兔子模型获得的药物药代动力学数据的适用性，在局部药物开发以及未来兔子与人之间的比较药物渗透研究中应予以考虑。
