Department of Hematology and Oncology, Department of Radiation Oncology, Case Comprehensive Cancer Center, 11100 Euclid Ave., Cleveland, OH, 44106, USA.
Department of Radiation Oncology, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, 11100 Euclid Ave., Cleveland, OH, 44106, USA.
Curr Treat Options Oncol. 2021 Jun 7;22(7):56. doi: 10.1007/s11864-021-00853-0.
Advanced non-melanoma skin cancers have been challenging to treat due to limited treatment options. Treatment paradigm has shifted with the approval of immunotherapeutic agents cemiplimab and pembrolizumab which have been a key development and have changed the landscape of advanced or metastatic squamous cell skin cancers. Hedgehog inhibitors, vismodegib and sonidegib, remain upfront options for advanced or metastatic basal cell carcinomas. Current clinical trials are continuing to evaluate the use of immune checkpoint inhibitors and hedgehog pathway inhibitors. There is further need for ongoing research and development of new therapies in both malignancies.
由于治疗选择有限，高级非黑色素瘤皮肤癌一直难以治疗。随着免疫治疗药物西普利单抗和帕博利珠单抗的批准，治疗模式发生了转变，这是一个关键的进展，改变了晚期或转移性鳞状细胞皮肤癌的治疗格局。 hedgehog 抑制剂维莫德吉和索尼德吉仍然是晚期或转移性基底细胞癌的一线选择。目前正在进行临床试验以评估免疫检查点抑制剂和 hedgehog 通路抑制剂的使用。在这两种恶性肿瘤中，需要进一步进行新疗法的研究和开发。
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