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英国 IBD 双胞胎注册研究:IBD 双胞胎的一致性和环境风险因素。

UK IBD Twin Registry: Concordance and Environmental Risk Factors of Twins with IBD.

机构信息

Department of Gastroenterology, Royal London Hospital, Whitechapel Rd, Whitechapel, London, E1 1FR, UK.

出版信息

Dig Dis Sci. 2022 Jun;67(6):2444-2450. doi: 10.1007/s10620-021-07080-5. Epub 2021 Jun 7.

DOI:10.1007/s10620-021-07080-5
PMID:34097167
Abstract

BACKGROUND AND AIMS

Twin studies have long been used to infer heritability. Within the 'omics era, twin cohorts have even greater research potential. This study describes the formation of the UK IBD Twin Registry and analysis of concordance and environmental factors.

METHOD

Twin pairs with IBD were recruited by advertising via IBD charities and social media, re-tracing a dormant IBD database and clinician referral. Details of zygosity, concordance, disease history and environmental factors were assessed. Pair concordance was calculated, and environmental factors were analysed with logistic regression models adjusted for zygosity and concordance.

RESULTS

Ninety-one twin pairs were included in the analysis; forty-two with CD and forty-nine with UC. More MZ twin pairs with CD were concordant compared with DZ pairs, thus inferring heritability (Chi-sq. 15.6. P < 0.001). In UC, MZ concordance was also numerically greater. Cigarette smoking was predictive of CD (OR 2.66, 95% CI 1.16 to 6.07 P = 0.02); there may be an independent association with cannabis smoking (OR 2.59 95% CI 0.89 to 7.55 P = 0.08). Breastfeeding was protective against UC (OR 0.48, 95% CI 0.25-0.93, P = 0.03), but not CD. Self-reports of less occurrences of gastroenteritis than peers were protective against future UC onset (OR 0.33 95% CI 0.15 to 0.74, P = 0.01). Method of delivery, parental attitudes towards hygiene and recall of diet did not impact future IBD concordance.

CONCLUSIONS

This study supports the heritability of IBD. Twin study analysis was able to elucidate environmental factors associated with IBD.

摘要

背景与目的

双胞胎研究长期以来一直被用于推断遗传率。在“组学”时代,双胞胎队列具有更大的研究潜力。本研究描述了英国 IBD 双胞胎登记处的形成,以及对一致性和环境因素的分析。

方法

通过 IBD 慈善机构和社交媒体广告招募 IBD 双胞胎,并重新追踪休眠的 IBD 数据库和临床医生转诊。评估了同卵双胞胎、一致性、疾病史和环境因素的详细信息。计算了双胞胎的一致性,并使用逻辑回归模型分析了环境因素,这些模型调整了同卵双胞胎和一致性。

结果

91 对双胞胎被纳入分析;42 对 CD 和 49 对 UC。与 DZ 对相比,更多的 CD 同卵双胞胎是一致的,因此推断出遗传率(Chi-sq. 15.6. P < 0.001)。在 UC 中,MZ 的一致性也更大。吸烟与 CD 相关(OR 2.66,95% CI 1.16-6.07 P = 0.02);可能与大麻吸烟有关(OR 2.59 95% CI 0.89-7.55 P = 0.08)。母乳喂养对 UC 有保护作用(OR 0.48,95% CI 0.25-0.93,P = 0.03),但对 CD 没有保护作用。与同龄人相比,自述肠胃炎发作次数较少对预防 UC 发病有保护作用(OR 0.33 95% CI 0.15-0.74,P = 0.01)。分娩方式、父母对卫生的态度和饮食回忆均未影响未来 IBD 的一致性。

结论

本研究支持 IBD 的遗传性。双胞胎研究分析能够阐明与 IBD 相关的环境因素。

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Inflamm Bowel Dis. 2015 Jun;21(6):1428-34. doi: 10.1097/MIB.0000000000000393.
Genes (Basel). 2022 Dec 16;13(12):2388. doi: 10.3390/genes13122388.
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Role of periostin in inflammatory bowel disease development and synergistic effects mediated by the CCL5-CCR5 axis.骨膜蛋白在炎症性肠病发展中的作用及其与 CCL5-CCR5 轴介导的协同作用。
Front Immunol. 2022 Oct 20;13:956691. doi: 10.3389/fimmu.2022.956691. eCollection 2022.
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Gastrointestinal Infections and the Risk of Inflammatory Bowel Disease in Twins and Siblings: Evidence Against the Hygiene Hypothesis.双胞胎和兄弟姐妹中的胃肠道感染与炎症性肠病风险:反对卫生假说的证据
Dig Dis Sci. 2022 Oct;67(10):4960-4961. doi: 10.1007/s10620-022-07670-x. Epub 2022 Aug 24.