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Alterations in AdeS and AdeR regulatory proteins in 1-(1-naphthylmethyl)-piperazine responsive colistin resistance of .1-(1-萘基甲基)哌嗪响应性黏菌素耐药. 中 AdeS 和 AdeR 调节蛋白的改变
J Chemother. 2020 Oct;32(6):286-293. doi: 10.1080/1120009X.2020.1735118. Epub 2020 Mar 5.
2
Diversity of amino acid substitutions in PmrCAB associated with colistin resistance in clinical isolates of Acinetobacter baumannii.多粘菌素耐药鲍曼不动杆菌临床分离株中 PmrCAB 相关氨基酸取代的多样性。
Int J Antimicrob Agents. 2020 Mar;55(3):105862. doi: 10.1016/j.ijantimicag.2019.105862. Epub 2019 Dec 16.
3
Antimicrobial Activity of Gallium Compounds on ESKAPE Pathogens.镓化合物对 ESKAPE 病原体的抗菌活性。
Front Cell Infect Microbiol. 2018 Sep 10;8:316. doi: 10.3389/fcimb.2018.00316. eCollection 2018.
4
Substrate Specificities and Efflux Efficiencies of RND Efflux Pumps of Acinetobacter baumannii.鲍曼不动杆菌 RND 外排泵的底物特异性和外排效率。
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5
Diversity of mutations in regulatory genes of resistance-nodulation-cell division efflux pumps in association with tigecycline resistance in Acinetobacter baumannii.在鲍曼不动杆菌中，与替加环素耐药性相关的抗性调节基因的突变多样性-结节-细胞分裂外排泵。
J Antimicrob Chemother. 2018 Jun 1;73(6):1501-1508. doi: 10.1093/jac/dky083.
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Single amino acid substitution Gly186Val in AdeS restores tigecycline susceptibility of Acinetobacter baumannii.AdeS 中单个氨基酸取代 Gly186Val 可恢复鲍曼不动杆菌对替加环素的敏感性。
J Antimicrob Chemother. 2016 Jun;71(6):1488-92. doi: 10.1093/jac/dkw002. Epub 2016 Feb 4.
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Exploring the proteomic characteristics of the Escherichia coli B and K-12 strains in different cellular compartments.探索大肠杆菌B株和K-12株在不同细胞区室中的蛋白质组学特征。
J Biosci Bioeng. 2016 Jul;122(1):1-9. doi: 10.1016/j.jbiosc.2015.12.005. Epub 2016 Jan 5.
8
The Asp20-to-Asn Substitution in the Response Regulator AdeR Leads to Enhanced Efflux Activity of AdeB in Acinetobacter baumannii.应答调节因子AdeR中Asp20到Asn的替换导致鲍曼不动杆菌中AdeB的外排活性增强。
Antimicrob Agents Chemother. 2015 Dec 7;60(2):1085-90. doi: 10.1128/AAC.02413-15. Print 2016 Feb.
9
Acinetobacter baumannii Virulence Is Mediated by the Concerted Action of Three Phospholipases D.鲍曼不动杆菌的毒力由三种磷脂酶 D 的协同作用介导。
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The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteria.革兰氏阴性菌中由外排介导的抗生素耐药性挑战。
Clin Microbiol Rev. 2015 Apr;28(2):337-418. doi: 10.1128/CMR.00117-14.

比较 AdeABC 外排泵介导的抗药性在鲍曼不动杆菌参考菌株 ATCC 17978 和 ATCC 19606 中的差异。

Comparison of the Acinetobacter baumannii Reference Strains ATCC 17978 and ATCC 19606 in Antimicrobial Resistance Mediated by the AdeABC Efflux Pump.

机构信息

Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Cologne, Germany.

German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany.

出版信息

Antimicrob Agents Chemother. 2021 Jul 16;65(8):e0057021. doi: 10.1128/AAC.00570-21.

DOI:10.1128/AAC.00570-21
PMID:34097477
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8284471/
Abstract

The Acinetobacter baumannii RND efflux pump AdeABC is regulated by the 2-component regulator AdeRS. In this study, we compared the regulation and expression of AdeABC of the reference strains ATCC 17978 and ATCC 19606. A clearly stronger efflux activity was demonstrated for ATCC 19606. An amino acid substitution at residue 172 of was identified as a potential cause for differential expression of the pump. Therefore, we recommend caution with exclusively using single reference strains for research.

摘要

鲍曼不动杆菌的 RND 外排泵 AdeABC 受双组分调控系统 AdeRS 调控。在本研究中，我们比较了参考菌株 ATCC 17978 和 ATCC 19606 中 AdeABC 的调控和表达情况。结果显示，ATCC 19606 的外排活性明显更强。我们发现 172 位氨基酸的替换可能是导致泵表达差异的潜在原因。因此，我们建议在研究中谨慎使用单一的参考菌株。