Wolf S M, Wagner J H, Davidson S, Forsythe A
Neurology. 1978 Feb;28(2):158-61. doi: 10.1212/wnl.28.2.158.
Two hundred thirty-nine patients with Bell palsy were randomly distributed into prednisone-treated and control groups. Patients were followed until complete recovery or for 1 year. In the steroid-treated and control groups, respectively, incomplete recovery of facial strength occurred in 12 percent and 20 percent; motor synkinesis in 9 percent and 15 percent; autonomic synkinesis in 1 percent and 10 percent; and electromyographic evidence of severe denervation in 9 percent and 17 percent. The differences reached statistical significance only for autonomic synkinesis. In the total series recovery of facial strength was incomplete in 16 percent. Residual weakness was mild in 14 percent and moderate in 2 percent. No patient remained with severe weakness. Age, hyperacusis, and severity of the initial palsy were associated with an increased risk of poor outcome.
239例贝尔麻痹患者被随机分为泼尼松治疗组和对照组。对患者进行随访，直至完全康复或满1年。在类固醇治疗组和对照组中，面部肌力未完全恢复的比例分别为12%和20%；出现联动运动的比例分别为9%和15%；出现自主神经联动的比例分别为1%和10%；肌电图显示严重失神经支配的比例分别为9%和17%。仅自主神经联动方面的差异具有统计学意义。在整个系列中，16%的患者面部肌力未完全恢复。14%的患者残留轻度无力，2%的患者残留中度无力。没有患者仍存在严重无力。年龄、听觉过敏和初始面瘫的严重程度与预后不良风险增加相关。
