Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty, Nilgiris, Tamil Nadu, India.
TIFAC CORE in Herbal Drugs, Department of Pharmacognosy, JSS Academy of Higher Education & Research, Ooty-643001, The Nilgiris, Tamil Nadu, India.
Exp Gerontol. 2021 Sep;152:111438. doi: 10.1016/j.exger.2021.111438. Epub 2021 Jun 8.
Cancer is one of the life-taking diseases worldwide and among cancer-related death; colorectal cancer is the third most. Though conventional methods of treatment are available, multidrug resistance and side effects are predominant. Physicians and scientists are working side by side to develop an effective medicament, which is safe and cost-effective. However, most failures are obtained when focused on the clinical perspective. This review mainly brings out the correlation between the curcumin and its use for the mitigation of colorectal cancer, the use of curcumin as a chemotherapeutic agent, chemosensitizer, and in a combination and synergistic approach. The pharmacokinetics and pharmacodynamics properties of curcumin and its formulation approach helps in giving an idea to develop new approaches for the treatment of colorectal cancer using curcumin.
癌症是全球范围内导致死亡的主要疾病之一，而在与癌症相关的死亡中，结直肠癌是第三大死因。尽管有常规的治疗方法，但多药耐药和副作用是主要问题。医生和科学家正在共同努力开发一种安全有效的药物。然而，当从临床角度来看时，大多数尝试都以失败告终。这篇综述主要阐述了姜黄素与其在缓解结直肠癌中的应用之间的相关性，将姜黄素用作化疗药物、化学增敏剂以及联合和协同作用的方法。姜黄素的药代动力学和药效学特性及其制剂方法有助于为使用姜黄素治疗结直肠癌开发新方法提供思路。
