State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, PR China.
Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, PR China.
Nano Lett. 2022 Aug 10;22(15):6156-6165. doi: 10.1021/acs.nanolett.2c01346. Epub 2022 Jul 19.
Overproduced hydrogen sulfide (HS) is a highly potential target for precise colorectal cancer (CRC) therapy; herein, a novel 5-Fu/Cur-P@HMPB nanomedicine is developed by coencapsulation of the natural anticancer drug curcumin (Cur) and the clinical chemotherapeutic drug 5-fluorouracil (5-Fu) into hollow mesoporous Prussian blue (HMPB). HMPB with low Fenton-catalytic activity can react with endogenous HS and convert into high Fenton-catalytic Prussian white (PW), which can generate a high level of OH to activate chemodynamic therapy (CDT) and meanwhile trigger autophagy. Importantly, the autophagy can be amplified by Cur to induce autophagic cell death; moreover, Cur also acted as a specific chemosensitizer of the chemotherapy drug 5-Fu, achieving a good synergistic antitumor effect. Such a triple synergistic therapy based on a novel nanomedicine has been verified both and to have high efficacy in CRC treatment, showing promising potential in translational medicine.
过表达的硫化氢 (HS) 是精准结直肠癌 (CRC) 治疗的一个极具潜力的靶点；在此，通过将天然抗癌药物姜黄素 (Cur) 和临床化疗药物 5-氟尿嘧啶 (5-Fu) 共包封到中空介孔普鲁士蓝 (HMPB) 中，开发了一种新型的 5-Fu/Cur-P@HMPB 纳米药物。具有低 Fenton 催化活性的 HMPB 可以与内源性 HS 反应，并转化为高 Fenton 催化的普鲁士白 (PW)，从而产生高水平的 OH 来激活化学动力学治疗 (CDT)，同时触发自噬。重要的是，Cur 可以放大自噬以诱导自噬细胞死亡；此外，Cur 还作为化疗药物 5-Fu 的特异性化疗增敏剂，实现了良好的协同抗肿瘤效果。这种基于新型纳米药物的三重协同治疗已被证明在 CRC 治疗中具有高效性，在转化医学中具有广阔的应用前景。
