ERAAP 功能的非经典免疫监视。
The nonclassical immune surveillance for ERAAP function.
机构信息
Department of Pathology and Institute of Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States.
Department of Pathology and Institute of Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States.
出版信息
Curr Opin Immunol. 2021 Jun;70:105-111. doi: 10.1016/j.coi.2021.05.008. Epub 2021 Jun 5.
The peptide repertoire presented by MHC class I molecules on the cell surface is essential for the immune surveillance of intracellular pathogens and transformed cells. The generation of this peptide repertoire is critically dependent on the endoplasmic reticulum aminopeptidase associated with antigen processing (ERAAP). Loss of ERAAP function leads to the generation of a profoundly disrupted peptide repertoire including many novel and immunogenic peptides. Strikingly, a large fraction of these novel peptides on ERAAP-KO cells are presented by the nonclassical MHC Ib molecule, Qa-1. One immunodominant Qa-1-restricted novel peptide is recognized by a unique CD8 T cell population showing features of both conventional cytotoxic T cells and unconventional innate-like T cells. While much remains to be uncovered, here we summarize the latest discoveries of our lab on the important immune surveillance of ERAAP function mediated by nonclassical MHC Ib molecules and their unusual cognate T cells.
MHC I 类分子在细胞表面呈现的肽库对于细胞内病原体和转化细胞的免疫监视至关重要。该肽库的产生严重依赖于与抗原加工相关的内质网氨肽酶（ERAAP）。ERAAP 功能的丧失会导致肽库严重紊乱，包括许多新的和免疫原性肽。引人注目的是，在 ERAAP-KO 细胞上的这些新肽中有很大一部分是由非经典 MHC Ib 分子 Qa-1 呈现的。一种免疫优势的 Qa-1 限制性新肽被一种独特的 CD8 T 细胞群体识别，该群体具有传统细胞毒性 T 细胞和非常规先天样 T 细胞的特征。虽然还有很多有待发现，但在这里，我们总结了我们实验室在非经典 MHC Ib 分子及其异常同源 T 细胞介导的 ERAAP 功能的重要免疫监视方面的最新发现。
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