身体疼痛与慢性病的关联：来自中国一项为期 7 年的基于人群的研究证据。

Association of body pain and chronic disease: evidence from a 7-year population-based study in China.

机构信息

Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital/National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Department of Biotherapy, National Clinical Research Center for Geriatrics, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

出版信息

Reg Anesth Pain Med. 2021 Sep;46(9):745-751. doi: 10.1136/rapm-2021-102700. Epub 2021 Jun 7.

DOI:10.1136/rapm-2021-102700

PMID:34099574

Abstract

BACKGROUND

Evidence is limited on the risk impact of body pain on future chronic disease. The present study aimed to investigate the association between body pain and chronic diseases.

METHODS

Data were analyzed using four waves of the China Health and Retirement Longitudinal Study with 17 708 individual respondents aged 45 years and older. The association between body pain and chronic disease was estimated in both a cross-sectional cohort (2011) and a longitudinal cohort (2011-2018). The key outcomes include the incidence of overall and any specific chronic diseases. The associations among different body pain sites and 10 independent chronic disease risks were also assessed.

FINDINGS

A total of 17 128 participants in 2011 were included in the cross-sectional cohort and 5611 participants were included in the 2011-2018 longitudinal cohort. Body pain showed an association with overall chronic disease in both the cross-sectional models (OR 2.71, 95% CI 2.47 to 2.98) and longitudinal model (risk ratio (RR) 1.21, 95% CI 1.07 to 1.35). Moreover, body pain was found to be associated with an increased risk of chronic respiratory disease (RR 1.43, 95% CI 1.06 to 1.92), heart disease (RR 1.45, 95% CI 1.12 to 1.89), kidney disease (RR 1.83, 95% CI 1.28 to 2.6), and digestive disease (RR 1.48, 95% CI 1.17 to 1.88).

CONCLUSION

Body pain is associated with major disease and mortality. Future clinical research should be targeted to whether or not improved pain control can mitigate this population-level disease burden.

摘要

背景

关于身体疼痛对未来慢性疾病风险影响的证据有限。本研究旨在探讨身体疼痛与慢性疾病之间的关系。

方法

使用中国健康与退休纵向研究的四波数据，对年龄在 45 岁及以上的 17708 名个体受访者进行了分析。在横断面队列（2011 年）和纵向队列（2011-2018 年）中估计了身体疼痛与慢性疾病之间的关系。主要结局包括总体和任何特定慢性疾病的发生率。还评估了不同身体疼痛部位与 10 种独立慢性疾病风险之间的关联。

结果

2011 年共纳入 17128 名参与者进行横断面队列研究，5611 名参与者纳入 2011-2018 年纵向队列研究。身体疼痛与横断面模型中的总体慢性疾病（OR 2.71，95%CI 2.47-2.98）和纵向模型（风险比（RR）1.21，95%CI 1.07-1.35）均相关。此外，身体疼痛与慢性呼吸道疾病（RR 1.43，95%CI 1.06-1.92）、心脏病（RR 1.45，95%CI 1.12-1.89）、肾病（RR 1.83，95%CI 1.28-2.6）和消化系统疾病（RR 1.48，95%CI 1.17-1.88）的风险增加相关。