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Coagulation factors and the incidence of COVID-19 severity: Mendelian randomization analyses and supporting evidence.

作者信息

Zhou Yao, Qian Xinyi, Liu Zipeng, Yang Hongxi, Liu Tong, Chen Kexin, Wang Yaogang, Sham Pak Chung, Yu Ying, Li Mulin Jun

机构信息

The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin Medical University, Tianjin, China.

Centre for PanorOmic Sciences-Genomics and Bioinformatics Cores, The University of Hong Kong, Hong Kong, China.

出版信息

Signal Transduct Target Ther. 2021 Jun 7;6(1):222. doi: 10.1038/s41392-021-00640-1.

DOI:10.1038/s41392-021-00640-1
PMID:34099622
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8181534/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af27/8184750/4056b9fde768/41392_2021_640_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af27/8184750/4056b9fde768/41392_2021_640_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af27/8184750/4056b9fde768/41392_2021_640_Fig1_HTML.jpg

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本文引用的文献

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N Engl J Med. 2020 Oct 15;383(16):1522-1534. doi: 10.1056/NEJMoa2020283. Epub 2020 Jun 17.
3
COVID-19: the vasculature unleashed.COVID-19：血管失控。
凝血生物标志物与2019冠状病毒病表型分析：一项前瞻性队列研究。
Thromb J. 2023 Jul 28;21(1):80. doi: 10.1186/s12959-023-00524-0.
4
Genome-wide cross-trait analysis and Mendelian randomization reveal a shared genetic etiology and causality between COVID-19 and venous thromboembolism.全基因组跨性状分析和孟德尔随机化揭示了 COVID-19 和静脉血栓栓塞之间存在共同的遗传病因和因果关系。
Commun Biol. 2023 Apr 21;6(1):441. doi: 10.1038/s42003-023-04805-2.
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Factor Xa cleaves SARS-CoV-2 spike protein to block viral entry and infection.因子 Xa 裂解 SARS-CoV-2 刺突蛋白以阻断病毒进入和感染。
Nat Commun. 2023 Apr 6;14(1):1936. doi: 10.1038/s41467-023-37336-9.
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