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ENO1 promotes antitumor immunity by destabilizing PD-L1 in NSCLC.ENO1通过使非小细胞肺癌中的PD-L1不稳定来促进抗肿瘤免疫。
Cell Mol Immunol. 2021 Aug;18(8):2045-2047. doi: 10.1038/s41423-021-00710-y. Epub 2021 Jun 7.
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Alpha-enolase promotes cell glycolysis, growth, migration, and invasion in non-small cell lung cancer through FAK-mediated PI3K/AKT pathway.α-烯醇化酶通过FAK介导的PI3K/AKT信号通路促进非小细胞肺癌细胞的糖酵解、生长、迁移和侵袭。
J Hematol Oncol. 2015 Mar 8;8:22. doi: 10.1186/s13045-015-0117-5.
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Serological proteome analysis approach-based identification of ENO1 as a tumor-associated antigen and its autoantibody could enhance the sensitivity of CEA and CYFRA 21-1 in the detection of non-small cell lung cancer.基于血清蛋白质组分析方法鉴定ENO1作为肿瘤相关抗原及其自身抗体可提高CEA和CYFRA 21-1在非小细胞肺癌检测中的敏感性。
Oncotarget. 2017 May 30;8(22):36664-36673. doi: 10.18632/oncotarget.17067.
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Preclinical validation of Alpha-Enolase (ENO1) as a novel immunometabolic target in multiple myeloma.α-烯醇化酶（ENO1）作为多发性骨髓瘤新型免疫代谢靶点的临床前验证。
Oncogene. 2020 Mar;39(13):2786-2796. doi: 10.1038/s41388-020-1172-0. Epub 2020 Feb 5.
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[ENO1 protein levels in the tumor tissues and circulating plasma samples of non-small cell lung cancer patients].非小细胞肺癌患者肿瘤组织及循环血浆样本中的ENO1蛋白水平
Zhongguo Fei Ai Za Zhi. 2010 Dec;13(12):1089-93. doi: 10.3779/j.issn.1009-3419.2010.12.02.
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Proteomic analysis of secreted proteins of non-small cell lung cancer.非小细胞肺癌分泌蛋白的蛋白质组学分析
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Non-small cell lung carcinomas with a minor sarcomatoid component and pleomorphic carcinomas are associated with high expression of programmed death ligand 1.具有小部分肉瘤样成分和多形性癌的非小细胞肺癌与程序性死亡配体 1 的高表达相关。
Pathol Res Pract. 2020 Dec;216(12):153238. doi: 10.1016/j.prp.2020.153238. Epub 2020 Oct 2.
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Non-small cell lung cancer with loss of expression of the SWI/SNF complex is associated with aggressive clinicopathological features, PD-L1-positive status, and high tumor mutation burden.SWI/SNF 复合物表达缺失的非小细胞肺癌与侵袭性临床病理特征、PD-L1 阳性状态和高肿瘤突变负担相关。
Lung Cancer. 2019 Dec;138:35-42. doi: 10.1016/j.lungcan.2019.10.009. Epub 2019 Oct 13.
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Anti-α-enolase is a prognostic marker in postoperative lung cancer patients.抗α-烯醇化酶是肺癌术后患者的一个预后标志物。
Oncotarget. 2015 Oct 27;6(33):35073-86. doi: 10.18632/oncotarget.5316.
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Ubiquitin C-terminal hydrolase L1 promotes expression of programmed cell death-ligand 1 in non-small-cell lung cancer cells.泛素羧基末端水解酶L1促进非小细胞肺癌细胞中程序性细胞死亡配体1的表达。
Cancer Sci. 2020 Sep;111(9):3174-3183. doi: 10.1111/cas.14529. Epub 2020 Jul 6.

引用本文的文献

1
Alpha-enolase promotes progression of acute myeloid leukemia via MAPK/ERK signaling pathway.α-烯醇化酶通过丝裂原活化蛋白激酶/细胞外信号调节激酶（MAPK/ERK）信号通路促进急性髓系白血病的进展。
Blood Sci. 2025 Aug 11;7(3):e00246. doi: 10.1097/BS9.0000000000000246. eCollection 2025 Sep.
2
Immunomodulatory behavior of CircRNAs in tumor microenvironment.环状RNA在肿瘤微环境中的免疫调节行为
Oncol Res. 2025 Apr 18;33(5):1105-1119. doi: 10.32604/or.2024.054623. eCollection 2025.
3
ENO1 promotes PDAC progression by inhibiting CD8 T cell infiltration through upregulating PD-L1 expression via HIF-1α signaling.ENO1通过HIF-1α信号上调PD-L1表达，抑制CD8 T细胞浸润，从而促进胰腺导管腺癌进展。
Transl Oncol. 2025 Feb;52:102261. doi: 10.1016/j.tranon.2024.102261. Epub 2025 Jan 2.
4
Role of ENO1 and its targeted therapy in tumors.ENO1 在肿瘤中的作用及其靶向治疗。
J Transl Med. 2024 Nov 14;22(1):1025. doi: 10.1186/s12967-024-05847-8.
5
O-GlcNAcylation of enolase 1 serves as a dual regulator of aerobic glycolysis and immune evasion in colorectal cancer.烯醇化酶 1 的 O-GlcNAc 化作为有氧糖酵解和结直肠癌免疫逃逸的双重调节剂。
Proc Natl Acad Sci U S A. 2024 Oct 29;121(44):e2408354121. doi: 10.1073/pnas.2408354121. Epub 2024 Oct 24.
6
Targeting MYC at the intersection between cancer metabolism and oncoimmunology.靶向癌症代谢与肿瘤免疫学交汇点的 MYC。
Front Immunol. 2024 Feb 8;15:1324045. doi: 10.3389/fimmu.2024.1324045. eCollection 2024.
7
Beyond , emerging roles and targeting strategies of other enolases in cancers.此外，其他烯醇化酶在癌症中的新作用和靶向策略。
Mol Ther Oncolytics. 2023 Nov 10;31:100750. doi: 10.1016/j.omto.2023.100750. eCollection 2023 Dec 19.
8
Association of Enolase-1 with Prognosis and Immune Infiltration in Breast Cancer by Clinical Stage.不同临床分期下烯醇化酶-1与乳腺癌预后及免疫浸润的相关性
J Inflamm Res. 2023 Feb 7;16:493-503. doi: 10.2147/JIR.S396321. eCollection 2023.
9
ENO1 Promotes OSCC Migration and Invasion by Orchestrating IL-6 Secretion from Macrophages via a Positive Feedback Loop.ENO1 通过正反馈环协调巨噬细胞中 IL-6 的分泌促进口腔鳞状细胞癌的迁移和侵袭。
Int J Mol Sci. 2023 Jan 1;24(1):737. doi: 10.3390/ijms24010737.
10
BIRC5 Modulates PD-L1 Expression and Immune Infiltration in Lung Adenocarcinoma.BIRC5调节肺腺癌中PD-L1的表达和免疫浸润。
J Cancer. 2022 Aug 21;13(10):3140-3150. doi: 10.7150/jca.69236. eCollection 2022.

ENO1 promotes antitumor immunity by destabilizing PD-L1 in NSCLC.

作者信息

Zhang Chunyi, Zhang Kunpeng, Gu Jie, Ge Di

机构信息

Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China.

Department of Chest Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.

出版信息

Cell Mol Immunol. 2021 Aug;18(8):2045-2047. doi: 10.1038/s41423-021-00710-y. Epub 2021 Jun 7.

DOI:10.1038/s41423-021-00710-y
PMID:34099892
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8322265/
Abstract
摘要