Department of Medicine, Surgery and Dentistry "Schola Medica Salernitana", University of Salerno, Baronissi, SA, Italy.
BIOUNIVERSA s.r.l., R&D Division, Baronissi, SA, Italy.
Br J Cancer. 2021 Sep;125(6):789-797. doi: 10.1038/s41416-021-01446-2. Epub 2021 Jun 7.
BAG3, a member of the BAG family of co-chaperones, is a multidomain protein with a role in several cellular processes, including the control of apoptosis, autophagy and cytoskeletal dynamics. The expression of bag3 is negligible in most cells but can be induced by stress stimuli or malignant transformation. In some tumours, BAG3 has been reported to promote cell survival and resistance to therapy. The expression of BAG3 has been documented in ovarian, endometrial and cervical cancers, and studies have revealed biochemical and functional connections of BAG3 with proteins involved in the survival, invasion and resistance to therapy of these malignancies. BAG3 expression has also been shown to correlate with the grade of dysplasia in squamous intraepithelial lesions of the uterine cervix. Some aspects of BAG3 activity, such as its biochemical and functional interaction with the human papillomavirus proteins, could help in our understanding of the mechanisms of oncogenesis induced by the virus. This review aims to highlight the potential value of BAG3 studies in the field of gynaecological tumours.
BAG3 是 BAG 家族伴侣蛋白的一个成员，是一种具有多种功能的蛋白，参与多种细胞过程，包括细胞凋亡、自噬和细胞骨架动力学的调控。BAG3 在大多数细胞中的表达可以忽略不计，但可以被应激刺激或恶性转化诱导。在一些肿瘤中，BAG3 被报道能促进细胞存活和对治疗的耐药性。BAG3 的表达已在卵巢癌、子宫内膜癌和宫颈癌中被记录，研究揭示了 BAG3 与参与这些恶性肿瘤存活、侵袭和耐药性的蛋白之间的生化和功能联系。BAG3 的表达与子宫颈鳞状上皮内病变的异型增生程度也有关。BAG3 活性的某些方面，如它与人类乳头瘤病毒蛋白的生化和功能相互作用，有助于我们理解病毒诱导的致癌机制。本综述旨在强调 BAG3 研究在妇科肿瘤领域的潜在价值。
