Dunaev V V, Tishkin V S, Milonova N P, Belaĭ I M, Makarenko A N
Farmakol Toksikol. 1988 May-Jun;51(3):21-5.
The effect of malic acid salts of iron, potassium, copper, chromium, lithium and zinc on the motor activity and electroencephalographic indices in rats was studied under the course of oral treatment (250 mg/kg). Potassium malate was found to exert the most pronounced stimulating effect on the motor activity and excitatory processes in the sensory motor brain areas. The study of the influence of this compound on total physical working capacity and its restoration revealed a significant dose-dependent stimulating action. It was shown that the effects of potassium malate are related to its ability to stimulate the most productive bioenergetic processes, to increase carbohydrate reserves, to decrease oxygen consumption of tissues.
研究了铁、钾、铜、铬、锂和锌的苹果酸盐在大鼠口服治疗(250毫克/千克)过程中对其运动活性和脑电图指标的影响。发现苹果酸钾对感觉运动脑区的运动活性和兴奋过程具有最显著的刺激作用。对该化合物对总体力工作能力及其恢复的影响的研究表明,其具有显著的剂量依赖性刺激作用。结果表明,苹果酸钾的作用与其刺激最高效生物能量过程、增加碳水化合物储备、降低组织耗氧量的能力有关。