Artamonov S D, Danilov M A, Kirpatovskiĭ V I, Burdina G V, Onishchenko N A
Farmakol Toksikol. 1988 May-Jun;51(3):27-30.
It was found that preliminary (before ischemia) administration of vitamin E in a dose of 200 mg/kg to albino rats causes the changes in energy support of the ischemic myocardium leading to prolonged maintenance of synthesis processes: energy production, cGMP concentration, unsaturation of cell membrane lipids increase. The combination of all these factors probably determines the anti-ischemic effect of vitamin E providing adequate restoration of the myocardial function in the postischemic period.
研究发现，对白化大鼠预先（缺血前）给予200毫克/千克剂量的维生素E，会导致缺血心肌的能量支持发生变化，从而使合成过程得以长期维持：能量产生、环磷酸鸟苷（cGMP）浓度增加，细胞膜脂质不饱和程度提高。所有这些因素的综合作用可能决定了维生素E的抗缺血作用，从而使缺血后心肌功能得到充分恢复。
