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饮食限制对青光眼的神经保护作用前景。

The promise of neuroprotection by dietary restriction in glaucoma.

作者信息

Russo Rossella, Nucci Carlo, Adornetto Annagrazia

机构信息

Preclinical and Translational Pharmacology, Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Italy.

Ophthalmology Unit, Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.

出版信息

Neural Regen Res. 2022 Jan;17(1):45-47. doi: 10.4103/1673-5374.314308.

DOI:10.4103/1673-5374.314308
PMID:34100425
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8451568/
Abstract

Glaucoma, a progressive age-related optic neuropathy characterized by the death of retinal ganglion cells, is the most common neurodegenerative cause of irreversible blindness worldwide. The therapeutic management of glaucoma, which is limited to lowering intraocular pressure, is still a challenge since visual loss progresses in a significant percentage of treated patients. Restricted dietary regimens have received considerable attention as adjuvant strategy for attenuating or delaying the progression of neurodegenerative diseases. Here we discuss the literature exploring the effects of modified eating patterns on retinal aging and resistance to stressor stimuli.

摘要

青光眼是一种与年龄相关的进行性视神经病变,其特征是视网膜神经节细胞死亡,是全球不可逆失明最常见的神经退行性病因。青光眼的治疗管理仅限于降低眼压,这仍然是一个挑战,因为在相当一部分接受治疗的患者中视力仍会继续丧失。限制饮食方案作为减轻或延缓神经退行性疾病进展的辅助策略受到了广泛关注。在此,我们讨论探索改良饮食模式对视网膜衰老和应激源刺激抵抗力影响的文献。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89ac/8451568/b4c66fb21277/NRR-17-45-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89ac/8451568/b4c66fb21277/NRR-17-45-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89ac/8451568/b4c66fb21277/NRR-17-45-g001.jpg

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1
The promise of neuroprotection by dietary restriction in glaucoma.饮食限制对青光眼的神经保护作用前景。
Neural Regen Res. 2022 Jan;17(1):45-47. doi: 10.4103/1673-5374.314308.
2
Effects of caloric restriction on retinal aging and neurodegeneration.热量限制对视网膜衰老和神经退行性变的影响。
Prog Brain Res. 2020;256(1):189-207. doi: 10.1016/bs.pbr.2020.07.005. Epub 2020 Aug 18.
3
Neuroprotection in glaucoma: Mechanisms beyond intraocular pressure lowering.青光眼的神经保护:眼压降低以外的机制。
Mol Aspects Med. 2023 Aug;92:101193. doi: 10.1016/j.mam.2023.101193. Epub 2023 Jun 16.
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Glaucomatous optic neuropathy management: the role of neuroprotective agents.青光眼性视神经病变的管理:神经保护剂的作用。
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Gene therapy for retinal ganglion cell neuroprotection in glaucoma.青光眼的视网膜神经节细胞基因治疗。
Gene Ther. 2012 Feb;19(2):127-36. doi: 10.1038/gt.2011.142. Epub 2011 Oct 6.
6
Neuroprotection in Glaucoma: Animal Models and Clinical Trials.青光眼的神经保护:动物模型和临床试验。
Annu Rev Vis Sci. 2017 Sep 15;3:91-120. doi: 10.1146/annurev-vision-102016-061422. Epub 2017 Jul 21.
7
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Nutrients. 2020 Oct 16;12(10):3158. doi: 10.3390/nu12103158.
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J Ocul Pharmacol Ther. 2018 Jan/Feb;34(1-2):85-106. doi: 10.1089/jop.2017.0041. Epub 2017 Aug 18.
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BMC Neurosci. 2017 Mar 1;18(1):27. doi: 10.1186/s12868-017-0346-3.

引用本文的文献

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Evaluating the impact of caloric restriction, body mass index and exercise on primary open-angle glaucoma: A review.评估热量限制、体重指数和运动对原发性开角型青光眼的影响:一项综述。
Eur J Ophthalmol. 2025 Mar;35(2):429-440. doi: 10.1177/11206721241274445. Epub 2024 Aug 22.
2
Epigenome-metabolism nexus in the retina: implications for aging and disease.视网膜中的表观基因组-代谢关联:衰老和疾病的影响。
Trends Genet. 2024 Aug;40(8):718-729. doi: 10.1016/j.tig.2024.04.012. Epub 2024 May 22.
3
Is Ultra-Processed Food Intake Associated with a Higher Risk of Glaucoma? A Prospective Cohort Study including 19,255 Participants from the SUN Project.

本文引用的文献

1
Effects of caloric restriction on retinal aging and neurodegeneration.热量限制对视网膜衰老和神经退行性变的影响。
Prog Brain Res. 2020;256(1):189-207. doi: 10.1016/bs.pbr.2020.07.005. Epub 2020 Aug 18.
2
Control of Inflammation by Calorie Restriction Mimetics: On the Crossroad of Autophagy and Mitochondria.热量限制模拟物对炎症的控制:自噬和线粒体的十字路口。
Cells. 2019 Dec 28;9(1):82. doi: 10.3390/cells9010082.
3
Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic Potential.热量限制类似物防治与年龄相关的疾病:靶点、机制和治疗潜力。
超加工食品摄入与青光眼风险增加有关吗?一项包括来自 SUN 项目的 19255 名参与者的前瞻性队列研究。
Nutrients. 2024 Apr 4;16(7):1053. doi: 10.3390/nu16071053.
4
A novel fixed-combination timolol-netarsudil-latanoprost ophthalmic solution for the treatment of glaucoma and ocular hypertension.一种用于治疗青光眼和高眼压症的新型噻吗洛尔-奈他洛尔-拉坦前列素固定复方眼用溶液。
Asian J Pharm Sci. 2022 Nov;17(6):938-948. doi: 10.1016/j.ajps.2022.11.001. Epub 2022 Nov 17.
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A Review on Peripheral Tinnitus, Causes, and Treatments from the Perspective of Autophagy.从自噬角度对周围性耳鸣、病因及治疗的综述
Exp Neurobiol. 2022 Aug 31;31(4):232-242. doi: 10.5607/en22002.
6
Intermittent Fasting to the Eye: A New Dimension Involved in Physiological and Pathological Changes.间歇性禁食对眼睛的影响:生理和病理变化中的一个新维度。
Front Med (Lausanne). 2022 May 24;9:867624. doi: 10.3389/fmed.2022.867624. eCollection 2022.
Cell Metab. 2019 Mar 5;29(3):592-610. doi: 10.1016/j.cmet.2019.01.018.
4
Rapamycin and fasting sustain autophagy response activated by ischemia/reperfusion injury and promote retinal ganglion cell survival.雷帕霉素和禁食通过缺血/再灌注损伤维持自噬反应并促进视网膜神经节细胞存活。
Cell Death Dis. 2018 Sep 24;9(10):981. doi: 10.1038/s41419-018-1044-5.
5
The effect of fasting or calorie restriction on autophagy induction: A review of the literature.禁食或热量限制对自噬诱导的影响:文献综述。
Ageing Res Rev. 2018 Nov;47:183-197. doi: 10.1016/j.arr.2018.08.004. Epub 2018 Aug 30.
6
Retinal changes in Parkinson's disease and glaucoma.帕金森病和青光眼的视网膜变化。
Parkinsonism Relat Disord. 2018 Nov;56:41-46. doi: 10.1016/j.parkreldis.2018.06.016. Epub 2018 Jun 21.
7
Caspases in retinal ganglion cell death and axon regeneration.半胱天冬酶在视网膜神经节细胞死亡和轴突再生中的作用
Cell Death Discov. 2017 Jul 3;3:17032. doi: 10.1038/cddiscovery.2017.32. eCollection 2017.
8
Age-related neurodegenerative disease associated pathways identified in retinal and vitreous proteome from human glaucoma eyes.从人青光眼眼中的视网膜和玻璃体蛋白质组中鉴定出与年龄相关的神经退行性疾病相关途径。
Sci Rep. 2017 Oct 4;7(1):12685. doi: 10.1038/s41598-017-12858-7.
9
Change in the Rate of Biological Aging in Response to Caloric Restriction: CALERIE Biobank Analysis.热量限制对生物衰老速率的影响:CALERIE生物样本库分析
J Gerontol A Biol Sci Med Sci. 2017 Dec 12;73(1):4-10. doi: 10.1093/gerona/glx096.
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Nutrition modulation of human aging: The calorie restriction paradigm.营养调控人类衰老:热量限制范式。
Mol Cell Endocrinol. 2017 Nov 5;455:148-157. doi: 10.1016/j.mce.2017.04.011. Epub 2017 Apr 12.