Reproductive Medical Center, The Second Hospital of Jilin University, Changchun, China.
Jilin Medical University, Jilin, China.
Reprod Sci. 2021 Dec;28(12):3303-3315. doi: 10.1007/s43032-021-00599-y. Epub 2021 Jun 8.
Recurrent spontaneous abortion affects approximately 1-2% of women of childbearing, and describes a condition in which women suffer from three or more continuous spontaneous miscarriages. However, the origin of recurrent spontaneous abortion (RSA) remains unknown, preventing effective treatment and placing stress upon patients. It has been acknowledged that successful pregnancy necessitates balanced immune responses. Therefore, immunological aberrancy may be considered a root cause of poor pregnancy outcomes. Considerable published studies have investigated the relationship between various immune cells and RSA. Here, we review current knowledge on this area, and discuss the five main categories of immune cells involved in RSA; these include innate lymphocytes (ILC), macrophages, decidual dendritic cells (DCs), and T cells. Furthermore, we sought to summarize the impact of the multiple interactions of various immune cells on the emergence of RSA. A good understanding of pregnancy-induced immunological alterations could reveal new therapeutic strategies for favorable pregnancy outcomes.
复发性自然流产影响大约 1-2%的育龄妇女，是指女性连续发生三次或三次以上的自然流产。然而，复发性自然流产（RSA）的病因仍不清楚，这使得无法进行有效的治疗，并给患者带来压力。人们已经认识到成功妊娠需要平衡的免疫反应。因此，免疫异常可能是不良妊娠结局的一个根本原因。大量已发表的研究调查了各种免疫细胞与 RSA 之间的关系。在这里，我们综述了这一领域的现有知识，并讨论了与 RSA 相关的五种主要免疫细胞类别；它们包括固有淋巴细胞（ILC）、巨噬细胞、蜕膜树突状细胞（DC）和 T 细胞。此外，我们还试图总结各种免疫细胞的多种相互作用对 RSA 发生的影响。深入了解妊娠诱导的免疫变化可能为良好的妊娠结局揭示新的治疗策略。
