Van Gaal L F, Nobels F R, Rillaerts E G, Creten W L, De Leeuw I H
Dept. Endocrinology, Metabolism and Nutrition, University of Antwerp Universiteitsplein, Wilrijk-Antwerp, Belgium.
Diabete Metab. 1988 May-Jun;14(3):289-93.
There is growing evidence that differences in fat distribution can be predictive for differences in the prevalence of metabolic disturbances, cardio-vascular disease, stroke and death, independent of commonly used indices of obesity. This study evaluates regional body fat distribution as a possible main reason for hypertension in obese and non-obese type II diabetics. 42% of normal weight diabetics with abdominal obesity are hypertensive versus 47% of obese diabetics; only 5% hypertension could be found when a lower body segment fat distribution is present. A significant (p less than 0.001) correlation exists between fat mass topography and both systolic (r = 0.49) and diastolic (r = 0.49) blood pressure. This correlation remains true after correction for body mass index and percent glycosylated hemoglobin. These results suggest that localization of fat in the upper body segment should be considered as a additive risk for hypertension.
越来越多的证据表明，脂肪分布的差异能够预测代谢紊乱、心血管疾病、中风及死亡发生率的差异，且独立于常用的肥胖指标。本研究评估了区域性体脂分布，将其作为肥胖和非肥胖II型糖尿病患者患高血压的一个可能主要原因。正常体重且腹部肥胖的糖尿病患者中42%患有高血压，而肥胖糖尿病患者中这一比例为47%；当下半身脂肪分布时，仅发现5%的患者患有高血压。脂肪量分布与收缩压（r = 0.49）和舒张压（r = 0.49）之间存在显著相关性（p小于0.001）。在校正体重指数和糖化血红蛋白百分比后，这种相关性依然成立。这些结果表明，上身部位脂肪的堆积应被视为高血压的一个附加风险因素。
