IEEE Trans Biomed Circuits Syst. 2021 Jun;15(3):537-548. doi: 10.1109/TBCAS.2021.3087475. Epub 2021 Aug 12.
This work presents a portable wireless urine detection system which consists of an electrochemical readout application specific integrated circuit (ASIC) and a biosensor composed of 2, 2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) and carbon nanotube (ABTS-CNT) for the detection of urine albumin-to-creatinine ratio (UACR). The ASIC includes a potentiostat, a digital circuitry and a power management circuit which can perform electrochemistry techniques with a dual-channel screen-printing carbon electrode (SPCE). Electrochemical experiments on the proposed biosensor (SPCE|ABTS-CNT|Nafion) have revealed promising sensing characteristics for creatinine and human serum albumin detection. Practical urine tests has demonstrated the capability of the proposed urine detection system for UACR detection with both the power-efficient readout ASIC and the ABTS-CNT biosensor. A user-friendly prototype has also been designed which can be useful for either personal health administrationor homecare.
本工作提出了一种便携式无线尿液检测系统，该系统由电化学读出应用特定集成电路 (ASIC) 和由 2,2'-联氮双(3-乙基苯并噻唑啉-6-磺酸)和碳纳米管 (ABTS-CNT) 组成的生物传感器组成，用于检测尿液白蛋白与肌酐比 (UACR)。该 ASIC 包括一个恒电位仪、一个数字电路和一个电源管理电路，可通过双通道丝网印刷碳电极 (SPCE) 执行电化学技术。对所提出的生物传感器 (SPCE|ABTS-CNT|Nafion) 的电化学实验显示了对肌酐和人血清白蛋白检测的有前途的传感特性。实际的尿液测试表明，该尿液检测系统具有使用低功耗读出 ASIC 和 ABTS-CNT 生物传感器进行 UACR 检测的能力。还设计了一个用户友好的原型，可用于个人健康管理或家庭护理。
