Translational Obstetrics Group, Mercy Hospital for Women, 163 Studley Road, Heidelberg, 3084, Victoria, Australia; The Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne, Victoria, Australia; Mercy Perinatal, Mercy Hospital for Women, Victoria, Australia.
Translational Obstetrics Group, Mercy Hospital for Women, 163 Studley Road, Heidelberg, 3084, Victoria, Australia; The Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne, Victoria, Australia; Mercy Perinatal, Mercy Hospital for Women, Victoria, Australia.
Placenta. 2021 Jul;110:24-28. doi: 10.1016/j.placenta.2021.05.007. Epub 2021 Jun 1.
Fetal growth restriction arising from placental insufficiency is a leading cause of stillbirth. We recently identified low maternal circulating SPINT1 concentrations as a novel biomarker of poor fetal growth. Here we measured SPINT1 in a prospective cohort in Singapore. Circulating SPINT1 concentrations were significantly lower among 141 pregnant women destined to deliver small-for-gestational age infants (birthweight <10th centile), compared to 772 controls (p < 0.01) at as early as 26 weeks' gestation. There were no correlations between infant body composition and circulating SPINT1 concentrations at 26 weeks. This provides validation that low maternal SPINT1 concentration is associated with poor fetal growth.
胎盘功能不全导致的胎儿生长受限是导致死产的主要原因。我们最近发现，母体循环中 SPINT1 浓度降低是胎儿生长不良的一种新的生物标志物。在这里，我们在新加坡的一个前瞻性队列中测量了 SPINT1。在妊娠 26 周时，与 772 名对照组（p<0.01）相比，141 名注定要分娩小于胎龄儿（出生体重<第 10 百分位）的孕妇的循环 SPINT1 浓度明显较低。在 26 周时，婴儿的身体成分与循环 SPINT1 浓度之间没有相关性。这证明了母体 SPINT1 浓度降低与胎儿生长不良有关。
