兔输卵管对电刺激收缩反应的肾上腺素能机制

Adrenergic mechanisms of the contractile response of rabbit oviduct to electrical stimulation.

Chernaeva L

Institute of Physiology, Bulgarian Academy of Sciences, Sofia.

Gen Pharmacol. 1988;19(4):625-30. doi: 10.1016/0306-3623(88)90175-9.

Abstract

In rabbit oviduct electrical field stimulation evoked contraction in mature animals and contraction followed by relaxation in juvenile animals. 2. Phentolamine (1 microM) inhibited the contraction. The relaxation was partly suppressed by propranolol (1-10 microM) and completely inhibited by guanethidine (5 microM). 3. Cocaine (1 microM) increased the duration or the amplitude of contractions and abolished or did not change the relaxation. The contraction-increasing effect of cocaine was more pronounced in estradiol-treated mature rabbit. 4. It is concluded that electrically evoked responses in rabbit oviduct are mediated by transmitters released from adrenergic terminals and that estradiol increases neuronal uptake of noradrenaline.

摘要

在兔输卵管中，电场刺激在成年动物中诱发收缩，而在幼年动物中则诱发收缩后松弛。2. 酚妥拉明（1微摩尔）抑制收缩。普萘洛尔（1 - 10微摩尔）部分抑制松弛，而胍乙啶（5微摩尔）完全抑制松弛。3. 可卡因（1微摩尔）增加收缩的持续时间或幅度，并消除或不改变松弛。可卡因的收缩增强作用在经雌二醇处理的成年兔中更明显。4. 得出结论，兔输卵管中的电诱发反应由肾上腺素能末梢释放的递质介导，且雌二醇增加去甲肾上腺素的神经元摄取。