Johns A, Paton D M
Can J Physiol Pharmacol. 1975 Dec;53(6):1172-7. doi: 10.1139/y75-162.
The influence of the adrenergic innervation on the magnitude of responses of the isthmus of rabbit oviduct to (-)-noradrenaline was examined. Tissues were obtained from estrogen-dominated animals, and isometric contractions of longitudinal and circular muscle layers separately recorded. Longitudinal muscle was significantly more sensitive to (-)-noradrenaline. Cocaine potentiated responses of both corcular and longitudinal muscle to (-)-noradrenaline, circular muscle being more potentiated. Similar results were obtained with desipramine. Tissues obtained from 6-hydroxydopamine pretreated animals did not respond to tyramine, and longitudinal and circular muscles were equisensitive to (-)-noradrenaline. Cocaine did not potentiate responses to (-)-noradrenaline in such tissues. Responses to (-)-noradrenaline were not altered by propranolol, hydrocortisone, or oxytetracycline. It was concluded that responses resulted from a predominant effect on alpha-receptors. The magnitude of responses to (-)-noradrenaline was mainly influenced by neuronal uptake of amine. Indirect evidence was obtained for a greater degree of adrenergic innervation to the circular muscle layer of the isthmus, in keeping with histological studies.
研究了肾上腺素能神经支配对兔输卵管峡部对（-）-去甲肾上腺素反应幅度的影响。组织取自雌激素占主导的动物，并分别记录纵行和环行肌层的等长收缩。纵行肌对（-）-去甲肾上腺素更为敏感。可卡因增强了环行肌和纵行肌对（-）-去甲肾上腺素的反应，环行肌增强更为明显。地昔帕明也得到了类似结果。取自6-羟基多巴胺预处理动物的组织对酪胺无反应，纵行肌和环行肌对（-）-去甲肾上腺素的敏感性相同。可卡因在此类组织中未增强对（-）-去甲肾上腺素的反应。普萘洛尔、氢化可的松或土霉素对（-）-去甲肾上腺素的反应无影响。得出的结论是，反应是由对α受体的主要作用引起的。对（-）-去甲肾上腺素的反应幅度主要受胺的神经元摄取影响。获得了间接证据，表明峡部环行肌层的肾上腺素能神经支配程度更高，这与组织学研究结果一致。
