通过模拟导入导管建模实现 SimVascular 中的真实边界条件。

Realistic boundary conditions in SimVascular through inlet catheter modeling.

机构信息

Department of Biomedical Engineering, University of California, Davis, One Shields Ave, Davis, CA, 95616-5270, USA.

Department of Mechanical and Aerospace Engineering, University of California, Los Angeles, 420 Westwood Plaza, Los Angeles, CA, 90095-1597, USA.

出版信息

BMC Res Notes. 2021 May 31;14(1):215. doi: 10.1186/s13104-021-05631-7.

DOI:10.1186/s13104-021-05631-7

PMID:34103097

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8186195/

Abstract

OBJECTIVE

This study aims at developing a pipeline that provides the capability to include the catheter effect in the computational fluid dynamics (CFD) simulations of the cardiovascular system and other human vascular flows carried out with the open-source software SimVascular. This tool is particularly useful for CFD simulation of interventional radiology procedures such as tumor embolization where estimation of a therapeutic agent distribution is of interest.

RESULTS

A pipeline is developed that generates boundary condition files which can be used in SimVascular CFD simulations. The boundary condition files are modified such that they simulate the effect of catheter presence on the flow field downstream of the inlet. Using this pipeline, the catheter flow, velocity profile, radius, wall thickness, and deviation from the vessel center can be defined. Since our method relies on the manipulation of the boundary condition that is imposed on the inlet, it is sensitive to the mesh density. The finer the mesh is (especially around the catheter wall), the more accurate the velocity estimations are. In this study, we also utilized this pipeline to qualitatively investigate the effect of catheter presence on the flow field in a truncated right hepatic arterial tree of a liver cancer patient.

摘要

目的

本研究旨在开发一个管道，为心血管系统的计算流体动力学（CFD）模拟以及使用开源软件 SimVascular 进行的其他人体血管流动提供将导管效应纳入其中的功能。该工具对于介入放射学程序（如肿瘤栓塞）的 CFD 模拟特别有用，在这些程序中，治疗剂分布的估计是感兴趣的。

结果

开发了一个生成边界条件文件的管道，这些文件可用于 SimVascular CFD 模拟。边界条件文件经过修改，以模拟导管存在对入口下游流场的影响。使用该管道，可以定义导管流量、速度剖面、半径、壁厚和偏离血管中心的程度。由于我们的方法依赖于对入口施加的边界条件的操纵，因此它对网格密度很敏感。网格越精细（特别是在导管壁周围），速度估计就越准确。在本研究中，我们还利用该管道定性研究了导管存在对肝癌患者右肝动脉树截断部分流场的影响。