有和没有遗尿症儿童的角回静息态活动与排尿欲望唤醒功能
The Resting-State Activities of the Angular Gyrus and the Micturition Desire-Awakening Function in Children With and Without Enuresis.
作者信息
Lin Xindi, Zhong Shaogen, Wang Mengxing, Mao Yi, Wu Yuhan, Lu Jiayi, Zhong Wei, Wu Di, Ma Jun
机构信息
Department of Developmental and Behavioral Pediatrics, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
College of Medical Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, China.
出版信息
Brain Behav. 2024 Dec;14(12):e70177. doi: 10.1002/brb3.70177.
BACKGROUND
Micturition desire-awakening (MDA) function plays a pivotal role in the development of primary nocturnal enuresis (PNE); however, its neural correlates remain largely unexplored. Consequently, this study aimed to identify specific brain regional activities associated with MDA function.
METHODS
Neuroimaging data were collected from 173 children with varying MDA functional grade scores at the Department of Developmental and Behavioral Pediatrics, Shanghai Children's Medical Center, from July 2018 to November 2022. Resting-state images were analyzed using whole-brain correlation techniques and AlphaSim correction to identify brain regional activities and resting-state functional connectivity (RSFC) associated with MDA functional grade scores.
RESULTS
Whole-brain correlation analysis demonstrated that the fractional amplitude of low-frequency fluctuations in the right angular gyrus (AG) exhibited a negative correlation with MDA functional grade scores (r = -0.336, p < 0.001), indicating reduced neural activity in this region with MDA dysfunction. Conversely, RSFC between the right middle frontal gyrus and the right AG was positively correlated with MDA functional grade scores (r = 0.274, p < 0.001), suggesting increased connectivity in these areas associated with worse MDA functionality.
CONCLUSION
These findings provide preliminary insights into the neural underpinnings of MDA functionality.
背景
排尿欲望唤醒（MDA）功能在原发性夜间遗尿症（PNE）的发生发展中起关键作用；然而，其神经关联仍 largely 未被探索。因此，本研究旨在确定与MDA功能相关的特定脑区活动。
方法
2018年7月至2022年11月期间，在上海儿童医学中心发育与行为儿科收集了173名具有不同MDA功能分级分数的儿童的神经影像数据。使用全脑相关技术和AlphaSim校正分析静息态图像，以确定与MDA功能分级分数相关的脑区活动和静息态功能连接（RSFC）。
结果
全脑相关分析表明，右侧角回（AG）低频波动的分数振幅与MDA功能分级分数呈负相关（r = -0.336，p < 0.001），表明该区域神经活动随着MDA功能障碍而减少。相反，右侧额中回与右侧AG之间的RSFC与MDA功能分级分数呈正相关（r = 0.274，p < 0.001），表明这些区域的连接增加与更差的MDA功能相关。
结论
这些发现为MDA功能的神经基础提供了初步见解。
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