具有里程碑意义的阿尔茨海默病药物获批令研究界感到困惑。 - Suppr

Landmark Alzheimer's drug approval confounds research community.

作者信息

Mullard Asher

出版信息

Nature. 2021 Jun;594(7863):309-310. doi: 10.1038/d41586-021-01546-2.

DOI:10.1038/d41586-021-01546-2

PMID:34103732

Abstract

摘要

相似文献

Landmark Alzheimer's drug approval confounds research community.

Nature. 2021 Jun;594(7863):309-310. doi: 10.1038/d41586-021-01546-2.

Recently Approved Alzheimer Drug Raises Questions That Might Never Be Answered.

JAMA. 2021 Aug 10;326(6):469-472. doi: 10.1001/jama.2021.11558.

Controversial Alzheimer's drug approval could affect other diseases.

Nature. 2021 Jul;595(7866):162-163. doi: 10.1038/d41586-021-01763-9.

Controversy and Progress in Alzheimer's Disease - FDA Approval of Aducanumab.

N Engl J Med. 2021 Aug 26;385(9):771-774. doi: 10.1056/NEJMp2111320. Epub 2021 Jul 28.

Aducanumab: The first targeted Alzheimer's therapy.

Drug Discov Ther. 2021;15(3):166-168. doi: 10.5582/ddt.2021.01061.

Treatments for Alzheimer's disease emerge.

Science. 2021 Aug 6;373(6555):624-626. doi: 10.1126/science.abi6401.

The antibody aducanumab reduces Aβ plaques in Alzheimer's disease.

Nature. 2016 Sep 1;537(7618):50-6. doi: 10.1038/nature19323.

Revisiting FDA Approval of Aducanumab.

N Engl J Med. 2021 Aug 26;385(9):769-771. doi: 10.1056/NEJMp2110468. Epub 2021 Jul 28.

Failed Alzheimer's trial does not kill leading theory of disease.

Nature. 2016 Nov 23;540(7631):15-16. doi: 10.1038/nature.2016.21045.

A carte blanche approval in Alzheimer's.

Nat Biotechnol. 2021 Jul;39(7):781. doi: 10.1038/s41587-021-00995-4.

引用本文的文献

Beyond Amyloid and Tau: The Critical Role of Microglia in Alzheimer's Disease Therapeutics.

Biomedicines. 2025 Jan 23;13(2):279. doi: 10.3390/biomedicines13020279.

Consuming a modified Mediterranean ketogenic diet reverses the peripheral lipid signature of Alzheimer's disease in humans.

Commun Med (Lond). 2025 Jan 9;5(1):11. doi: 10.1038/s43856-024-00682-w.

Involvement of Complement in Alzheimer's Disease: From Genetics Through Pathology to Therapeutic Strategies.

Curr Top Behav Neurosci. 2025;69:3-24. doi: 10.1007/7854_2024_524.

Electrical brain networks before and after transcranial pulsed shockwave stimulation in Alzheimer's patients.

Geroscience. 2025 Feb;47(1):953-964. doi: 10.1007/s11357-024-01305-x. Epub 2024 Aug 27.

Nonlipogenic ABCA1 Inducers (NLAI) for Alzheimer's Disease Validated in a Mouse Model Expressing Human .

J Med Chem. 2024 Sep 12;67(17):15061-15079. doi: 10.1021/acs.jmedchem.4c00733. Epub 2024 Aug 27.

A Systematic Online Living Evidence Summary of experimental Alzheimer's disease research.

J Neurosci Methods. 2024 Sep;409:110209. doi: 10.1016/j.jneumeth.2024.110209. Epub 2024 Jul 2.

Current Progress in Magnetic Resonance-Guided Focused Ultrasound to Facilitate Drug Delivery across the Blood-Brain Barrier.

Pharmaceutics. 2024 May 27;16(6):719. doi: 10.3390/pharmaceutics16060719.

Promising Strategies to Reduce the SARS-CoV-2 Amyloid Deposition in the Brain and Prevent COVID-19-Exacerbated Dementia and Alzheimer's Disease.

Pharmaceuticals (Basel). 2024 Jun 16;17(6):788. doi: 10.3390/ph17060788.

Validation of a functional human AD model with four AD therapeutics utilizing patterned iPSC-derived cortical neurons integrated with microelectrode arrays.

Res Sq. 2024 May 20:rs.3.rs-4313679. doi: 10.21203/rs.3.rs-4313679/v1.

Parvalbumin Interneuron Dysfunction in Neurological Disorders: Focus on Epilepsy and Alzheimer's Disease.

Int J Mol Sci. 2024 May 19;25(10):5549. doi: 10.3390/ijms25105549.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验

Landmark Alzheimer's drug approval confounds research community.

作者信息

出版信息

相似文献

引用本文的文献

文献AI研究员

用中文搜PubMed

文档翻译

Suppr 超能文献

Landmark Alzheimer's drug approval confounds research community.

作者信息

出版信息

相似文献

引用本文的文献