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Treatments for Alzheimer's disease emerge.

作者信息

Selkoe Dennis J

机构信息

Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

出版信息

Science. 2021 Aug 6;373(6555):624-626. doi: 10.1126/science.abi6401.

DOI:10.1126/science.abi6401
PMID:34353940
Abstract
摘要

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Treatments for Alzheimer's disease emerge.治疗阿尔茨海默病的方法出现了。
Science. 2021 Aug 6;373(6555):624-626. doi: 10.1126/science.abi6401.
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Drugs: a tangled web of targets.药物：一张错综复杂的靶点网络。
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Mechanism-based treatments for Alzheimer's disease.基于机制的阿尔茨海默病治疗方法。
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Alzheimer's disease: Mental plaque removal.阿尔茨海默病：清除脑内斑块。
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Shutting down Alzheimer's.攻克阿尔茨海默病。
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Protein aggregation in Alzheimer's disease: Aβ and τ and their potential roles in the pathogenesis of AD.阿尔茨海默病中的蛋白质聚集：淀粉样β蛋白和τ蛋白及其在阿尔茨海默病发病机制中的潜在作用。
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Are antibodies directed against amyloid-β (Aβ) oligomers the last call for the Aβ hypothesis of Alzheimer's disease?针对淀粉样β（Aβ）寡聚体的抗体是阿尔茨海默病Aβ假说的最后希望吗？
Immunotherapy. 2019 Jan;11(1):3-6. doi: 10.2217/imt-2018-0119.
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Inhibition of glutaminyl cyclase ameliorates amyloid pathology in an animal model of Alzheimer's disease via the modulation of γ-secretase activity.在阿尔茨海默病动物模型中，谷氨酰胺环化酶的抑制通过调节γ-分泌酶活性改善淀粉样病理。
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Zileuton improves memory deficits, amyloid and tau pathology in a mouse model of Alzheimer's disease with plaques and tangles.齐留通可改善阿尔茨海默病斑块和缠结小鼠模型的记忆缺陷、淀粉样蛋白和tau 病理。
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