Hu Yan, Ni Jiao
Department of Infection, Zhuji People's Hospital of Zhejiang Province, Zhuji, Zhejiang, China.
Xiaoshan District Chengxiang Street Community Health Service Center, Hangzhou, Zhejiang, China.
Des Monomers Polym. 2021 May 31;24(1):173-181. doi: 10.1080/15685551.2021.1935010.
A new Cd(II) coordination polymer with the formula of {[(CH)NH][Cd(NH-bdc)(btz)(HO)]} ( NH-Hbdc = 2-aminoterephthalic acid, Hbtz = 1 H-benzotriazole) was produced and then it was structurally characterized through powder X-ray diffraction (PXRD), the analysis of X-ray single-crystal diffraction, along with elemental analysis (EA). The photocatalytic property investigations indicate that compound exhibits good activity for photodegradation of methyl violet (MV) with 60.7% of MV removal in 40 min under room temperature. Furthermore, the assessment of the compound's treatment activity and nursing application values on the bacterial infection was conducted and its corresponding mechanism was also studied. Evaluation of the in vitro hemolysis of the compound was determined by measuring the degree of red blood cell lysis and hemoglobin release. The effect of new compounds on the relative proliferation rate of L-929 cells was measured by MTT assay. The ELISA detection kit showed that the compound could reduce the TNF-α and IL-1β content released into plasma. Next, the inhibitory activity of the compound on the bacterial survival gene expression was also proved with real-time RT-PCR. The hemolysis rate of the new compound to blood is 3.4%, which is less than the standard 5%, which is non-hemolytic reaction. The compound also has no obvious cytotoxicity and has good cell compatibility.
合成了一种新的分子式为{[(CH)NH][Cd(NH-bdc)(btz)(HO)]}的镉（II）配位聚合物（NH-Hbdc = 2-氨基对苯二甲酸，Hbtz = 1H-苯并三唑），然后通过粉末X射线衍射（PXRD）、X射线单晶衍射分析以及元素分析（EA）对其结构进行了表征。光催化性能研究表明，该化合物在室温下对甲基紫（MV）的光降解表现出良好的活性，40分钟内MV去除率为60.7%。此外，还对该化合物对细菌感染的治疗活性和护理应用价值进行了评估，并研究了其相应机制。通过测量红细胞裂解程度和血红蛋白释放量来测定该化合物的体外溶血情况。采用MTT法测定新化合物对L-929细胞相对增殖率的影响。ELISA检测试剂盒表明，该化合物可降低血浆中释放的TNF-α和IL-1β含量。接下来，通过实时RT-PCR也证明了该化合物对细菌生存基因表达的抑制活性。新化合物对血液的溶血率为3.4%，低于标准的5%，属于非溶血反应。该化合物也没有明显的细胞毒性，具有良好的细胞相容性。
