Garrett John S, Vanston Annelise, Nguyen Hoa L, Cassity Cindy, Straza Angela
Department of Healthcare Quality and Patient Safety, Baylor University Medical Center, Dallas, TX, USA.
Department of Population and Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA, USA.
J Clin Med Res. 2021 May;13(5):304-308. doi: 10.14740/jocmr4498. Epub 2021 May 25.
Unintended overdoses of opiate medications are potentially lethal events. Monitoring patients for oversedation is fundamental to ensuring safe use of opiates, and the timing of this evaluation is guided by the onset of action, time to max effect and duration of action of the opiate. The study's aim was to describe the timing of oversedation in relation to the predicted duration of action of the administered opiate.
This study was conducted as a retrospective review of all opiate-related oversedation events during a 2-year period involving patients admitted to an urban teaching hospital.
Of the 53 opiate-related oversedation events evaluated, 47% occurred after the predicted maximal duration of action of the administered opiate.
Opiate-induced oversedation routinely occurs after predicted based upon duration of action. The study findings have profound implications upon nursing practice regarding duration of time required to monitor for opiate-induced oversedation.
阿片类药物意外过量服用可能导致致命后果。监测患者是否过度镇静是确保阿片类药物安全使用的基础，而该评估的时机由阿片类药物的起效时间、达到最大效应的时间及作用持续时间决定。本研究的目的是描述与所给予阿片类药物预测作用持续时间相关的过度镇静发生时间。
本研究通过回顾性分析一家城市教学医院在两年期间收治的所有与阿片类药物相关的过度镇静事件进行。
在所评估的53例与阿片类药物相关的过度镇静事件中，47%发生在所给予阿片类药物预测的最大作用持续时间之后。
基于作用持续时间预测，阿片类药物引起的过度镇静通常会在预测时间之后发生。该研究结果对护理实践中监测阿片类药物引起的过度镇静所需的时间具有深远影响。
