B10小鼠对查巴迪疟原虫的抗性：H-2复合体和睾酮的影响
Resistance to Plasmodium chabaudi in B10 mice: influence of the H-2 complex and testosterone.
作者信息
Wunderlich F, Mossmann H, Helwig M, Schillinger G
机构信息
Division of Parasitology, University of Duesseldorf, Federal Republic of Germany.
出版信息
Infect Immun. 1988 Sep;56(9):2400-6. doi: 10.1128/iai.56.9.2400-2406.1988.
Abstract
Resistance to Plasmodium chabaudi has been examined in different inbred mouse strains bearing identical H-2 haplotypes on different genetic backgrounds as well as in H-2-congenic mouse strains on B10 background. Resistance is expressed in terms of percent survival after a challenge with 10(6) P. chabaudi-infected erythrocytes. We can show that murine resistance to P. chabaudi is under complex polygenic control involving a non-H-2 gene(s) as well as genes in both I-A and I-E subregions of the H-2 complex. Our data indicate in particular that malaria protective antigens can be presented in context with I-Ab molecules but not in context with I-Ak molecules. Resistance controlled by I-Ab does not become apparent when I-Ek molecules are coincidentally expressed. Moreover, testosterone abrogates I-Ab-controlled resistance to P. chabaudi.
摘要
在不同遗传背景下携带相同H-2单倍型的近交系小鼠品系以及B10背景的H-2同基因小鼠品系中，对查巴迪疟原虫的抗性已得到研究。抗性通过用10(6)个感染查巴迪疟原虫的红细胞进行攻击后存活百分比来表示。我们可以证明，小鼠对查巴迪疟原虫的抗性受复杂的多基因控制，涉及一个非H-2基因以及H-2复合体的I-A和I-E亚区中的基因。我们的数据特别表明，疟疾保护性抗原可以与I-Ab分子结合呈递，但不能与I-Ak分子结合呈递。当I-Ek分子同时表达时，由I-Ab控制的抗性并不明显。此外，睾酮可消除I-Ab控制的对查巴迪疟原虫的抗性。
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