Hou Jiale, Long Tingting, He Zhiyou, Zhou Ming, Yang Nengan, Chen Dengming, Zeng Shan, Hu Shuo
Department of Nuclear Medicine, XiangYa Hospital, Central South University, No. 87 XiangYa Road, ChangSha, Hunan Province, People's Republic of China.
Department of Cancer Chemotherapy, XiangYa Hospital, Central South University, No. 87 XiangYa Road, ChangSha, Hunan Province, People's Republic of China.
EJNMMI Res. 2021 Jun 9;11(1):55. doi: 10.1186/s13550-021-00797-4.
To evaluate the diagnostic efficacy of F-AlF-NOTA-octreotide (F-OC) PET/CT compared with that of Ga-DOTATATE PET/CT.
Twenty patients (mean age: 52.65 years, range: 24-70 years) with biopsy-proven neuroendocrine neoplasms (NENs) were enrolled in this prospective study. We compared the biodistribution profiles in normal organs based on the maximum standard uptake value (SUV) and mean standard uptake value (SUV), and uptake in NEN lesions by measuring the SUV on F-OC and Ga-DOTATATE PET/CT images. The tumor-to-liver ratio (TLR) and tumor-to-spleen ratio were calculated by dividing the SUV of different tumor lesions by the SUV of the liver and spleen, respectively. The Wilcoxon signed-rank test was used to compare nonparametric data. Data were expressed as the median (interquartile range).
In most organs, there were no significant differences in the biodistribution of Ga-DOTATATE and F-OC. F-OC had significantly lower uptake in the salivary glands and liver than Ga-DOTATATE. F-OC detected more lesions than Ga-DOTATATE. The uptake of F-OC in the tumors was higher in most patients, but the difference was not statistically significant relative to that of Ga-DOTATATE. However, the TLRs of F-OC were higher in most patients, including for lesions in the liver (p = 0.02) and lymph nodes (p = 0.02).
Relative to Ga-DOTATATE, F-OC possesses favorable characteristics with similar image quality and satisfactory NEN lesion detection rates, especially in the liver due to its low background uptake. F-OC therefore offers a promising clinical alternative for Ga-DOTATATE.
评估F-AlF-NOTA-奥曲肽（F-OC）PET/CT与Ga-DOTATATE PET/CT相比的诊断效能。
20例经活检证实为神经内分泌肿瘤（NENs）的患者（平均年龄：52.65岁，范围：24 - 70岁）纳入本前瞻性研究。我们基于最大标准摄取值（SUV）和平均标准摄取值（SUV）比较了正常器官中的生物分布情况，并通过测量F-OC和Ga-DOTATATE PET/CT图像上的SUV来比较NEN病变中的摄取情况。肿瘤与肝脏比值（TLR）和肿瘤与脾脏比值分别通过将不同肿瘤病变的SUV除以肝脏和脾脏的SUV来计算。采用Wilcoxon符号秩检验比较非参数数据。数据以中位数（四分位间距）表示。
在大多数器官中，Ga-DOTATATE和F-OC的生物分布无显著差异。F-OC在唾液腺和肝脏中的摄取明显低于Ga-DOTATATE。F-OC检测到的病变比Ga-DOTATATE更多。大多数患者中F-OC在肿瘤中的摄取较高，但与Ga-DOTATATE相比差异无统计学意义。然而，大多数患者中F-OC的TLR更高，包括肝脏病变（p = 0.02）和淋巴结病变（p = 0.02）。
相对于Ga-DOTATATE，F-OC具有良好的特性，图像质量相似且NEN病变检测率令人满意，尤其是在肝脏中因其背景摄取较低。因此，F-OC为Ga-DOTATATE提供了一种有前景的临床替代方案。
