Erasmus MC, University Medical Center Rotterdam, Department of Medical Microbiology and Infectious Diseases, Rotterdam, The Netherlands.
Mycetoma Research Center, University of Khartoum, Khartoum, Sudan.
PLoS Negl Trop Dis. 2021 Jun 9;15(6):e0009488. doi: 10.1371/journal.pntd.0009488. eCollection 2021 Jun.
Mycetoma is a devastating neglected tropical infection of the subcutaneous tissue and most commonly caused by the fungus Madurella mycetomatis. Treatment of mycetoma consists of a combination of a long term antifungal treatment with itraconazole and surgery. However, treatment is associated with low success rates. Therefore, there is a need to identify novel treatments for mycetoma. CIN-102 is a synthetic partial copy of cinnamon oils with activity against many pathogenic bacteria and fungi. In this study we determined the in vitro activity of CIN-102 against 21 M. mycetomatis isolates and its in vivo efficacy in a M. mycetomatis infected Galleria mellonella larval model. In vitro, CIN-102 was active against M. mycetomatis with MICs ranging from 32 μg/mL to 512 μg/mL. 128 μg/mL was needed to inhibit the growth in 50% of tested isolates. In vivo, concentrations below the MIC of 40 mg/kg and 80 mg/kg CIN-102 prolonged larval survival, but higher concentrations of CIN-102 did not.
足菌肿是一种严重的被忽视的热带感染，主要由真菌马杜拉分枝霉菌引起。足菌肿的治疗包括长期抗真菌治疗联合伊曲康唑和手术。然而，治疗的成功率较低。因此，需要寻找新的足菌肿治疗方法。CIN-102 是肉桂油的合成部分拷贝，对许多致病性细菌和真菌具有活性。在这项研究中，我们测定了 CIN-102 对 21 株马杜拉分枝霉菌分离株的体外活性及其在感染马杜拉分枝霉菌的金龟子幼虫模型中的体内疗效。体外，CIN-102 对马杜拉分枝霉菌具有活性，MIC 范围为 32 μg/ml 至 512 μg/ml。抑制 50%受试分离株生长需要 128 μg/ml。体内，低于 MIC 的 40 mg/kg 和 80 mg/kg CIN-102 浓度延长了幼虫的存活时间，但更高浓度的 CIN-102 则没有。
