Al Nasr Ibrahim S, Koko Waleed S, Khan Tariq A, Schobert Rainer, Biersack Bernhard
Department of Biology, College of Science, Qassim University, Qassim 51452, Saudi Arabia.
Department of Basic Health Sciences, College of Applied Medical Sciences, Qassim University, Qassim 51452, Saudi Arabia.
Antibiotics (Basel). 2024 Nov 22;13(12):1114. doi: 10.3390/antibiotics13121114.
New drugs for the treatment of protozoal parasite infections such as toxoplasmosis and leishmaniasis are required. Cinnamaldehyde and its derivatives appear to be promising antiparasitic drug candidates. Acyl hydrazones of cinnamaldehyde, 4-dimethylaminocinnamaldehyde, and of the synthetic fragrances silvial and florhydral were prepared and tested for activity against () and () parasites. Three cinnamaldehyde acyl hydrazones (3-hydroxy-2-naphthoyl and the salicyloyls and ) showed good activity against , and two compounds derived from cinnamaldehyde and florhydral (3-hydroxy-2-naphthoyls and ) exhibited moderate activity against promastigotes. In particular, the identified antitoxoplasmal activities are promising and might lead to the development of new potent and cost-effective drug candidates for the therapy of toxoplasmosis.
需要用于治疗原生动物寄生虫感染（如弓形虫病和利什曼病）的新药。肉桂醛及其衍生物似乎是有前景的抗寄生虫药物候选物。制备了肉桂醛、4-二甲基氨基肉桂醛以及合成香料银醛和花香醛的酰腙，并测试了它们对（）和（）寄生虫的活性。三种肉桂醛酰腙（3-羟基-2-萘甲酰基和水杨酰基和）对显示出良好的活性，两种源自肉桂醛和花香醛的化合物（3-羟基-2-萘甲酰基和）对前鞭毛体表现出中等活性。特别是，所确定的抗弓形虫活性很有前景，可能会促成开发用于治疗弓形虫病的新的高效且经济有效的药物候选物。
