Svendsen J, Larsen J L
Nord Vet Med. 1977 Dec;29(12):533-8.
Milk from sows whose progeny developed post weaning E. coli diarrhoea (PWD milk) and from sows which were immunized by intramuscular vaccination using a homologous strain of E. coli (immune milk) were tested in ligated segments of pig intestine. The results showed that PWD milk neutralized the enterotoxigenic, fluid accumulating capacity of the lysate of the disease-causing E. coli pathogen. A similar effect was seen by using immune milk (Table I). Neither PWD milk nor immune milk contained sufficient antibacterial activity to neutralize the fluid accumulating capacity of live cultures of E. coli O149:K91, while such activity was contained in immune serum. It is concluded that milk from sows whose progeny developed PWD contains antibodies capable of neutralizing the enterotoxigenic effects of the homologous E. coli organisms. It is suggested that the presence in milk from these sows of antibody-mediated activity against enteropathogenic E. coli organisms may be instrumental in preventing the disease in the progeny during the suckling period and consequently, when this protective milk supply stops at weaning, the disease may develop in susceptible animals, mainly because their own production of specific E. coli antibodies is insufficient to prevent PWD.
对后代发生断奶后大肠杆菌腹泻的母猪的乳汁（断奶后腹泻乳汁）以及通过肌肉注射同源大肠杆菌菌株进行免疫的母猪的乳汁（免疫乳汁），在猪肠道结扎段进行了测试。结果表明，断奶后腹泻乳汁中和了致病性大肠杆菌病原体裂解物的产肠毒素、积液能力。使用免疫乳汁也观察到了类似效果（表一）。断奶后腹泻乳汁和免疫乳汁均未含有足够的抗菌活性来中和大肠杆菌O149:K91活培养物的积液能力，而免疫血清中则含有这种活性。得出的结论是，后代发生断奶后腹泻的母猪的乳汁含有能够中和同源大肠杆菌生物产肠毒素作用的抗体。有人提出，这些母猪的乳汁中存在针对致病性大肠杆菌生物的抗体介导活性，可能有助于在哺乳期间预防后代发病，因此，当断奶时这种保护性乳汁供应停止，易感动物可能会发病，主要是因为它们自身产生的特异性大肠杆菌抗体不足以预防断奶后腹泻。
