Pérez-Bosque Anna, Polo Javier, Torrallardona David
Grup de Fisiologia digestiva i adaptacions nutricionals, Departament de Bioquímica i Fisiologia, Facultat de Farmàcia i Ciències de l'Alimentació, Institut de Recerca en Nutrició i Seguretat Alimentària, Universitat de Barcelona (UB), Barcelona, Spain.
APC Europe, S.A., Granollers, Spain.
Porcine Health Manag. 2016 Jul 23;2:16. doi: 10.1186/s40813-016-0034-1. eCollection 2016.
The use of growth promoting and therapeutic antibiotics in piglet feed has been a concerning subject over the last few decades because of the risk of generating antimicrobial resistance that could be transferred to humans. As a result, many products have been proposed as potential alternatives to the use of antibiotics, and among these, spray dried plasma is considered one of the most promising. However, there have been concerns about its biosafety, particularly during periods of emergence or re-emergence of swine diseases in different regions of the world, such as the recent porcine epidemic diarrhea virus outbreak in North America. The objectives of this paper are to review recent publications about the use of spray dried plasma as an alternative to antibiotics in weaned pig diets, the possible mechanisms of action of spray dried plasma, and the existing evidence related to the biosafety of spray dried animal plasma. Particular attention is given to studies in which spray dried plasma has been directly compared to antibiotics or other alternative antimicrobial products. Several studies on the possible modes of action for spray dried plasma, such as preservation of gut barrier function or modulation of the immune response, are also reviewed. Finally, the paper focuses on the review of the existing studies on the risks of disease transmission with the use of spray dried plasma from porcine origin. Overall, spray dried plasma is a promising alternative to in-feed antimicrobials for piglets, particularly during the early stages of the post-weaning phase. Additionally, there is enough evidence to support that commercial spray dried porcine plasma is a safe product for pigs.
在过去几十年里，仔猪饲料中使用促生长和治疗性抗生素一直是一个备受关注的问题，因为存在产生可传播给人类的抗菌耐药性的风险。因此，许多产品被提议作为抗生素使用的潜在替代品，其中喷雾干燥血浆被认为是最有前景的替代品之一。然而，人们对其生物安全性存在担忧，特别是在世界不同地区猪病出现或再次出现的时期，例如最近北美爆发的猪流行性腹泻病毒。本文的目的是综述关于在断奶仔猪日粮中使用喷雾干燥血浆替代抗生素的最新出版物、喷雾干燥血浆可能的作用机制以及与喷雾干燥动物血浆生物安全性相关的现有证据。特别关注将喷雾干燥血浆与抗生素或其他替代抗菌产品直接比较的研究。还综述了一些关于喷雾干燥血浆可能的作用方式的研究，如维持肠道屏障功能或调节免疫反应。最后，本文重点回顾了关于使用猪源喷雾干燥血浆传播疾病风险的现有研究。总体而言，喷雾干燥血浆是仔猪饲料中抗菌剂的一种有前景的替代品，特别是在断奶后阶段的早期。此外，有足够的证据支持商业喷雾干燥猪血浆对猪来说是一种安全的产品。
