大肠杆菌中同功tRNA浓度的遗传决定差异。
Genetically determined differences in concentrations of isoaccepting tRNAs in Escherichia coli.
作者信息
Thomale J, Nass G
出版信息
Nucleic Acids Res. 1977 Dec;4(12):4313-22. doi: 10.1093/nar/4.12.4313.
Abstract
Two examples of genetically determined altered concentrations of isoaccepting tRNAs are presented. The concentrations of isoaccepting tRNAsThr are selectively changed by a mutation causing a fourfold overproduction of the cognate aminoacyl-tRNA-synthetase, the threonyl-tRNA synthetase, whereas the distribution of isoaccepting tRNAs of four control tRNA-species in these E. coli mutants was not affected by that mutation. Secondly evidence is presented for a correlation between mutations in structural genes of aminoacid biosynthetic enzymes and alterations in concentrations of cognate isoaccepting tRNAs in two different E. coli strains, auxotrophic for threonine, isoleucine/valine and leucine, and arginine respectively.
摘要
本文给出了两个由基因决定的同功tRNA浓度改变的例子。导致同源氨酰tRNA合成酶（苏氨酰tRNA合成酶）产量增加四倍的突变，选择性地改变了同功tRNAThr的浓度，而在这些大肠杆菌突变体中，四种对照tRNA种类的同功tRNA分布不受该突变影响。其次，本文还给出证据表明，在分别对苏氨酸、异亮氨酸/缬氨酸和亮氨酸以及精氨酸营养缺陷的两种不同大肠杆菌菌株中，氨基酸生物合成酶结构基因的突变与同源同功tRNA浓度的改变之间存在相关性。
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