Applied Microfluidics for BioEngineering Research, MESA+ Institute for Nanotechnology & TechMed Center, University of Twente, Enschede, The Netherlands.
Laboratory of Organic Chemistry, Wageningen University, Wageningen, The Netherlands.
Commun Biol. 2021 Jun 9;4(1):704. doi: 10.1038/s42003-021-02155-5.
Organosilicon compounds are ubiquitous in everyday use. Application of some of these compounds in food, cosmetics and pharmaceuticals is widespread on the assumption that these materials are not systemically absorbed. Here the interactions of various organosilicon compounds (simeticone, hexamethyldisilazane and polydimethylsiloxane) with cell membranes and models thereof were characterized with a range of analytical techniques, demonstrating that these compounds were retained in or on the cell membrane. The increasing application of organosilicon compounds as replacement of other plastics calls for a better awareness and understanding of these interactions. Moreover, with many developments in biotechnology relying on organosilicon materials, it becomes important to scrutinize the potential effect that silicone leaching may have on biological systems.
有机硅化合物在日常生活中无处不在。由于这些材料不会被系统性地吸收，因此一些有机硅化合物被广泛应用于食品、化妆品和药品中。本研究利用一系列分析技术，对不同有机硅化合物（二甲硅油、六甲基二硅氮烷和聚二甲基硅氧烷）与细胞膜及其模型的相互作用进行了表征，结果表明这些化合物被保留在细胞膜内或细胞膜上。由于有机硅化合物作为其他塑料的替代品的应用越来越广泛，因此需要更好地了解和认识这些相互作用。此外，随着生物技术的许多发展都依赖于有机硅材料，因此有必要仔细研究硅酮浸出可能对生物系统产生的潜在影响。
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