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了解严重急性呼吸综合征冠状病毒2(SARS-CoV-2)以减轻当前及未来的大流行。

Understanding the SARS-CoV-2 virus to mitigate current and future pandemic(s).

作者信息

Mohanty Swaraj, Paul Subhojit, Ahmad Yasmin

机构信息

Peptide and Proteomics Division, Defence Institute of Physiology and Allied Sciences (DIPAS), Defence R&D Organization (DRDO), Lucknow Road, Timarpur, Delhi 110054 India.

出版信息

Virusdisease. 2021 Sep;32(3):390-399. doi: 10.1007/s13337-021-00696-1. Epub 2021 Jun 5.

Abstract

Micro-organisms form the first pioneer community in the history of biological life, thought to be present in the primordial soup and evolving later with more complex life-forms. Among micro-organisms, viruses form a separate taxon of organisms. Viruses are obligate parasites, being inactive without a host and becoming active once in contact with specific hosts. Viruses, with an inherent ability to infect and hijack cellular structures, have been utilised as vectors to introduce foreign genetic material in a variety of biological species, e.g. adenoviral vectors. However, viruses have also been the root cause of many infectious diseases, most notable being HIV-AIDS, for its resistance to treatment and omnipresent occurrence. There are many families of viruses like retroviridae, picornaviridae and poxviridae. This review focuses on a specific member of the coronaviridae, the SARS-CoV-2. This virus is responsible for the current COVID-19 pandemic. This review summarises its transmission, molecular mechanism by which it causes disease, associated clinical symptoms and the strategies available to control it from sources like PubMed, Google Scholar, webservers of National Institute of Health (NIH), European Molecular Biology Laboratory (EMBL), World Health Organisation (WHO), United States Food and Drug Administration (USFDA) and Centers for Disease Control and Prevention (CDC) available as on 1st May 2021.

摘要

微生物构成了生物生命史上的首个先锋群落,被认为存在于原始汤中,并随着更复杂的生命形式而进化。在微生物中,病毒构成了一个独立的生物分类单元。病毒是专性寄生虫,没有宿主时处于不活跃状态,一旦与特定宿主接触就会变得活跃。病毒具有感染和劫持细胞结构的内在能力,已被用作载体在多种生物物种中引入外源遗传物质,例如腺病毒载体。然而,病毒也是许多传染病的根源,最著名的是艾滋病毒/艾滋病,因为它难以治疗且广泛存在。病毒有许多科,如逆转录病毒科、小核糖核酸病毒科和痘病毒科。本综述聚焦于冠状病毒科的一个特定成员,即严重急性呼吸综合征冠状病毒2(SARS-CoV-2)。这种病毒是当前新冠肺炎大流行的元凶。本综述总结了其传播方式、致病的分子机制、相关临床症状以及截至2021年5月1日从PubMed、谷歌学术、美国国立卫生研究院(NIH)、欧洲分子生物学实验室(EMBL)、世界卫生组织(WHO)、美国食品药品监督管理局(USFDA)和疾病控制与预防中心(CDC)等来源获取的控制该病毒的可用策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3dba/8473469/6343a1bfdfea/13337_2021_696_Fig1_HTML.jpg

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