• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

医学成像数据的 3D 混合现实可视化作为支持工具，用于创新的、微创的胃肠道肿瘤手术和全身治疗，作为先进癌症疾病个体化治疗的新途径。

3D mixed-reality visualization of medical imaging data as a supporting tool for innovative, minimally invasive surgery for gastrointestinal tumors and systemic treatment as a new path in personalized treatment of advanced cancer diseases.

机构信息

Department of Surgical Oncology, NEO HOSPITAL Sp. z o. o. ONE Sp. k., Ul. Józefa Kostrzewskiego 47, 30-437, Kraków, Poland.

Department of Clinical Oncology, NEO HOSPITAL Sp. z o. o. ONE Sp. k., Ul. Józefa Kostrzewskiego 47, 30-437, Kraków, Poland.

出版信息

J Cancer Res Clin Oncol. 2022 Jan;148(1):237-243. doi: 10.1007/s00432-021-03680-w. Epub 2021 Jun 10.

DOI:10.1007/s00432-021-03680-w
PMID:34110490
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8752560/
Abstract

BACKGROUND

The purpose of this study was to investigate the potential of a combination of 3D mixed-reality visualization of medical images using CarnaLife Holo (MedApp, Poland) system as a supporting tool for innovative, minimally invasive surgery/irreversible electroporation-IRA, Nano-Knife), microwave ablation (MWA)/for advanced gastrointestinal tumors. Eight liver and pancreatic tumor treatments were performed. In all of the patients undergoing laparoscopy or open surgery volume and margin were estimated by preoperative visualization. In all patients, neoplastic lesions were considered unresectable by standard methods.

METHODS

Preoperative CT or MRI were transformed into holograms and displayed thanks to the HoloLens 2. During operation, the surgeon's field of view was augmented with a 3D model of the patient's relevant structures.

RESULTS

The intraoperative hologram contributed to better presentation of tumor size and locations, more precise setting of needles used to irreversible electroporation and for determining ablation line in case of liver metastases. Surgeons could easily compare the real patient's anatomy to holographic visualization just before the operations.

CONCLUSIONS

The combination of 3D mixed-reality visualization using CarnaLife Holo with IRA, MWA and next systemic treatment (chemotherapy) might be a new way in personalized treatment of advanced cancers.

摘要

背景

本研究的目的是探讨使用 CarnaLife Holo（MedApp，波兰）系统进行医学图像的 3D 混合现实可视化，作为创新的、微创手术/不可逆电穿孔-IRA、纳米刀、微波消融（MWA）/治疗先进的胃肠道肿瘤的辅助工具的潜力。对 8 例肝和胰腺肿瘤进行了治疗。在所有接受腹腔镜或剖腹手术的患者中，通过术前可视化来估计体积和边缘。所有患者的肿瘤病变均被认为是通过标准方法不可切除的。

方法

术前 CT 或 MRI 转化为全息图，并通过 HoloLens 2 显示。在手术过程中，外科医生的视野通过患者相关结构的 3D 模型进行增强。

结果

术中全息图有助于更好地呈现肿瘤的大小和位置，更精确地设置用于不可逆电穿孔的针，并确定肝转移的消融线。外科医生可以在手术前轻松地将真实患者的解剖结构与全息可视化进行比较。

结论

使用 CarnaLife Holo 进行 3D 混合现实可视化与 IRA、MWA 和下一次系统治疗（化疗）相结合，可能是治疗晚期癌症的一种新方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e17/11801142/30a70f4c0e34/432_2021_3680_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e17/11801142/5ec4334cbc5b/432_2021_3680_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e17/11801142/8c981c3480b8/432_2021_3680_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e17/11801142/30a70f4c0e34/432_2021_3680_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e17/11801142/5ec4334cbc5b/432_2021_3680_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e17/11801142/8c981c3480b8/432_2021_3680_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e17/11801142/30a70f4c0e34/432_2021_3680_Fig3_HTML.jpg

相似文献

1
3D mixed-reality visualization of medical imaging data as a supporting tool for innovative, minimally invasive surgery for gastrointestinal tumors and systemic treatment as a new path in personalized treatment of advanced cancer diseases.医学成像数据的 3D 混合现实可视化作为支持工具，用于创新的、微创的胃肠道肿瘤手术和全身治疗，作为先进癌症疾病个体化治疗的新途径。
J Cancer Res Clin Oncol. 2022 Jan;148(1):237-243. doi: 10.1007/s00432-021-03680-w. Epub 2021 Jun 10.
2
Augmented visualization with depth perception cues to improve the surgeon's performance in minimally invasive surgery.增强深度感知提示的可视化效果，以提高微创手术中外科医生的表现。
Med Biol Eng Comput. 2019 May;57(5):995-1013. doi: 10.1007/s11517-018-1929-6. Epub 2018 Dec 4.
3
Intraoperative 3D Hologram Support With Mixed Reality Techniques in Liver Surgery.术中混合现实技术的 3D 全息图支持在肝脏手术中的应用。
Ann Surg. 2020 Jan;271(1):e4-e7. doi: 10.1097/SLA.0000000000003552.
4
Comparison of Chronologic Change in the Size and Contrast-Enhancement of Ablation Zones on CT Images after Irreversible Electroporation and Radiofrequency Ablation.不可逆电穿孔与射频消融术后 CT 图像上消融区域大小和增强程度的时相变化比较。
Korean J Radiol. 2018 Jul-Aug;19(4):560-567. doi: 10.3348/kjr.2018.19.4.560. Epub 2018 Jun 14.
5
[Simulation and Navigation in the Neurosurgical Field Using Three-Dimensional Hholograms by Mixed Reality Devices].[使用混合现实设备通过三维全息图在神经外科领域进行模拟和导航]
No Shinkei Geka. 2024 Mar;52(2):248-253. doi: 10.11477/mf.1436204908.
6
A new technique for minimally invasive irreversible electroporation of tumors in the head and body of the pancreas.一种用于胰腺头部和体部肿瘤微创不可逆电穿孔的新技术。
Surg Endosc. 2017 Apr;31(4):1982-1985. doi: 10.1007/s00464-016-5173-6. Epub 2016 Aug 29.
7
Irreversible electroporation for colorectal cancer liver metastasis: a review.不可逆电穿孔治疗结直肠癌肝转移：综述
Int J Hyperthermia. 2022;39(1):682-687. doi: 10.1080/02656736.2021.2008025.
8
Augmented environments for the targeting of hepatic lesions during image-guided robotic liver surgery.增强环境在图像引导机器人肝切除术中靶向肝病变的应用。
J Surg Res. 2013 Oct;184(2):825-31. doi: 10.1016/j.jss.2013.04.032. Epub 2013 May 8.
9
Experimental Setup Employed in the Operating Room Based on Virtual and Mixed Reality: Analysis of Pros and Cons in Open Abdomen Surgery.基于虚拟现实和混合现实的手术室实验设置：开放性腹部手术中的优缺点分析。
J Healthc Eng. 2020 Aug 6;2020:8851964. doi: 10.1155/2020/8851964. eCollection 2020.
10
3D mixed reality holograms for preoperative surgical planning of nephron-sparing surgery: evaluation of surgeons' perception.3D 混合现实全息图在保肾手术术前规划中的应用：对外科医生感知的评估。
Minerva Urol Nephrol. 2021 Jun;73(3):367-375. doi: 10.23736/S2724-6051.19.03610-5. Epub 2019 Sep 5.

引用本文的文献

1
Usefulness of Mixed Reality in Surgical Treatment: Delphi Study.混合现实在外科治疗中的效用：德尔菲研究。
J Med Internet Res. 2025 Jul 8;27:e69964. doi: 10.2196/69964.
2
Mixed reality guidance in osteotomy provides superior precision and accuracy: validation and comparative study.截骨术中的混合现实引导提供了更高的精度和准确性：验证与比较研究。
Int Orthop. 2025 Jun 11. doi: 10.1007/s00264-025-06574-5.
3
Accurate Medical Vial Identification Through Mixed Reality: A HoloLens 2 Implementation.通过混合现实实现精确的医用小瓶识别：HoloLens 2的应用

本文引用的文献

1
Augmented reality and mixed reality for healthcare education beyond surgery: an integrative review.增强现实和混合现实在手术之外的医疗保健教育中的应用：综合评价。
Int J Med Educ. 2020 Jan 18;11:1-18. doi: 10.5116/ijme.5e01.eb1a.
2
Virtual, augmented, and mixed reality applications in orthopedic surgery.骨科手术中的虚拟现实、增强现实和混合现实应用。
Int J Med Robot. 2020 Apr;16(2):e2067. doi: 10.1002/rcs.2067. Epub 2020 Feb 6.
3
Intraoperative 3D Hologram Support With Mixed Reality Techniques in Liver Surgery.术中混合现实技术的 3D 全息图支持在肝脏手术中的应用。
Electronics (Basel). 2024 Nov 2;13(22):4420. doi: 10.3390/electronics13224420. Epub 2024 Nov 11.
4
An attempt to evaluate the use of mixed reality in surgically treated pediatric oncology patients.一项评估混合现实技术在接受手术治疗的儿科肿瘤患者中的应用的尝试。
NPJ Digit Med. 2025 May 9;8(1):262. doi: 10.1038/s41746-025-01638-7.
5
Technological Advancements in Augmented, Mixed, and Virtual Reality Technologies for Surgery: A Systematic Review.用于手术的增强现实、混合现实和虚拟现实技术的技术进展：一项系统综述。
Cureus. 2024 Dec 26;16(12):e76428. doi: 10.7759/cureus.76428. eCollection 2024 Dec.
6
Mixed Reality Biopsy Navigation System Utilizing Markerless Needle Tracking and Imaging Data Superimposition.利用无标记针跟踪和成像数据叠加的混合现实活检导航系统。
Cancers (Basel). 2024 May 16;16(10):1894. doi: 10.3390/cancers16101894.
7
Mixed Reality in Modern Surgical and Interventional Practice: Narrative Review of the Literature.现代外科与介入实践中的混合现实：文献综述
JMIR Serious Games. 2023 Jan 6;11:e41297. doi: 10.2196/41297.
8
Mixed reality navigation training system for liver surgery based on a high-definition human cross-sectional anatomy data set.基于高清人体横断面解剖数据集的肝外科混合现实导航培训系统。
Cancer Med. 2023 Apr;12(7):7992-8004. doi: 10.1002/cam4.5583. Epub 2023 Jan 6.
9
Microsoft HoloLens 2 in Medical and Healthcare Context: State of the Art and Future Prospects.微软 HoloLens 2 在医疗保健领域的应用：现状与未来展望。
Sensors (Basel). 2022 Oct 11;22(20):7709. doi: 10.3390/s22207709.
Ann Surg. 2020 Jan;271(1):e4-e7. doi: 10.1097/SLA.0000000000003552.
4
Use of mixed reality for improved spatial understanding of liver anatomy.使用混合现实技术改善对肝脏解剖结构的空间理解。
Minim Invasive Ther Allied Technol. 2020 Jun;29(3):154-160. doi: 10.1080/13645706.2019.1616558. Epub 2019 May 22.
5
First-in-man experience with real-time holographic mixed reality display of three-dimensional echocardiography during structural intervention: balloon mitral commissurotomy.在结构性干预（球囊二尖瓣交界切开术）期间，三维超声心动图实时全息混合现实显示的人体首次体验。
Eur Heart J. 2020 Feb 1;41(6):801. doi: 10.1093/eurheartj/ehz127.
6
Augmented reality in open surgery.开放手术中的增强现实技术。
Updates Surg. 2018 Sep;70(3):389-400. doi: 10.1007/s13304-018-0567-8. Epub 2018 Jul 13.
7
Mixed Reality with HoloLens: Where Virtual Reality Meets Augmented Reality in the Operating Room.使用HoloLens的混合现实：虚拟现实与增强现实在手术室的交汇之处。
Plast Reconstr Surg. 2017 Nov;140(5):1066-1070. doi: 10.1097/PRS.0000000000003802.
8
Irreversible electroporation (Nanoknife® treatment) in the field of hepatobiliary surgery: Current status and future perspectives.不可逆电穿孔（纳米刀®治疗）在肝胆外科领域的现状与未来展望。
J BUON. 2017 Jan-Feb;22(1):141-149.
9
Time-Dependent Impact of Irreversible Electroporation on Pancreas, Liver, Blood Vessels and Nerves: A Systematic Review of Experimental Studies.不可逆电穿孔对胰腺、肝脏、血管和神经的时间依赖性影响：实验研究的系统评价
PLoS One. 2016 Nov 21;11(11):e0166987. doi: 10.1371/journal.pone.0166987. eCollection 2016.
10
Evaluation of tolerability and efficacy of irreversible electroporation (IRE) in treatment of Child-Pugh B (7/8) hepatocellular carcinoma (HCC).不可逆电穿孔（IRE）治疗Child-Pugh B级（7/8分）肝细胞癌（HCC）的耐受性和疗效评估。
HPB (Oxford). 2016 Jul;18(7):593-9. doi: 10.1016/j.hpb.2016.03.609. Epub 2016 May 1.