Department of Dermatology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Department of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Mycoses. 2021 Oct;64(10):1170-1176. doi: 10.1111/myc.13295. Epub 2021 Jun 27.
Talaromyces marneffei, formerly known as Penicillium marneffei, is a significant emerging pathogenic fungus in Southeast Asia which can generate life-threatening systemic infections. Human immunodeficiency virus (HIV) infection is considered as the most underlying disease among systemic infections. However, infections due to T. marneffei without HIV are increasing in recent years.
Research the characteristics of T. marneffei infection in non-HIV individuals in mainland China.
In this study, we searched Pubmed, China National Knowledge Infrastructure (CNKI) and WanFang from inception to 31 December 2019 for studies reporting T. marneffei infection. Our research concentrates on non-HIV-infected cases and their epidemiology, clinical manifestations, laboratory findings, treatment methods and prognosis.
T. marneffei infections in non-HIV individuals are increasing. Due to frequent present with atypical symptoms, these non-HIV-infected cases were usually misdiagnosed as other diseases, containing tuberculosis (80.7%), bacterial pneumonia (20.5%), lung cancer (5.1%) or other diseases (5.1%).
T. marneffei infection in non-HIV individuals should be taken seriously. Their symptoms and signs are not typical. Accurate diagnosis and timely antifungal agent treatment is the key to the treatment for the disease.
马尔尼菲青霉，以前被称为彭萨皮里厄斯·马内菲，是东南亚一种重要的新兴致病真菌，可引起危及生命的全身性感染。人类免疫缺陷病毒（HIV）感染被认为是全身性感染中最根本的疾病。然而，近年来，由于马尔尼菲青霉而没有 HIV 的感染也在增加。
研究中国大陆非 HIV 个体中马尔尼菲青霉感染的特征。
本研究检索了 Pubmed、中国知网（CNKI）和万方，从建库到 2019 年 12 月 31 日，以检索报告马尔尼菲青霉感染的研究。我们的研究集中在非 HIV 感染的病例及其流行病学、临床表现、实验室检查、治疗方法和预后。
非 HIV 个体中的马尔尼菲青霉感染正在增加。由于常伴有不典型症状，这些非 HIV 感染的病例通常被误诊为其他疾病，包括肺结核（80.7%）、细菌性肺炎（20.5%）、肺癌（5.1%）或其他疾病（5.1%）。
非 HIV 个体中的马尔尼菲青霉感染应引起重视。其症状和体征不典型。准确的诊断和及时的抗真菌药物治疗是治疗该病的关键。
