Peng Juan, Chen Zhiyong, Cai Ruiming, Huang Xianen, Lin Liying, Liang Weixiang, Xiong Zhongtang, Chen Juan, Chen Hui, Yang Yuexin, Liu Shaoyan, Jiang Qingping
Department of Pathology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Department of Organ Transplantation, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Transpl Infect Dis. 2017 Aug;19(4). doi: 10.1111/tid.12710. Epub 2017 Jun 7.
Talaromyces marneffei is an emerging opportunistic infection among immunocompromised patients. We observe the first native case of disseminated T. marneffei involving the kidney in a renal transplant recipient in mainland China. We describe the comprehensive clinical course, and ultrasound imaging of renal transplant biopsy, pathologic images, and electron microscopy observation of the biopsy specimen, highlighting the relevance of biopsy findings and the blood culture. We also focus on the treatment and good outcome of the patient. Then we review the literature and show the additional 10 reported cases of T. marneffei in renal transplant recipients. In addition, we discuss the new methods of rapid diagnosis of T. marneffei. In brief, timely diagnosis and proper treatment of T. marneffei infection is important in renal transplant recipients.
马尔尼菲篮状菌是免疫功能低下患者中一种新出现的机会性感染病原体。我们观察到中国大陆一名肾移植受者出现首例播散性马尔尼菲篮状菌累及肾脏的本土病例。我们描述了其全面的临床病程、肾移植活检的超声成像、病理图像以及活检标本的电子显微镜观察结果，强调了活检结果和血培养的相关性。我们还重点介绍了该患者的治疗情况及良好预后。随后我们回顾了文献，并展示了另外10例肾移植受者中报道的马尔尼菲篮状菌病例。此外，我们讨论了马尔尼菲篮状菌的快速诊断新方法。简而言之，及时诊断和恰当治疗马尔尼菲篮状菌感染对于肾移植受者至关重要。
