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发育性语言障碍与精神病理学:厘清共同的遗传和环境影响。

Developmental Language Disorder and Psychopathology: Disentangling Shared Genetic and Environmental Influences.

机构信息

University of York, UK.

King's College London, UK.

出版信息

J Learn Disabil. 2022 May-Jun;55(3):185-199. doi: 10.1177/00222194211019961. Epub 2021 Jun 11.

DOI:10.1177/00222194211019961
PMID:34112015
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8996291/
Abstract

There is considerable variability in the extent to which young people with developmental language disorder (DLD) experience mental health difficulties. What drives these individual differences remains unclear. In the current article, data from the Twin Early Development Study were used to investigate the genetic and environmental influences on psychopathology in children and adolescents with DLD ( = 325) and those without DLD ( = 865). Trivariate models were fitted to investigate etiological influences on DLD and psychopathology, and bivariate heterogeneity and homogeneity models were fitted and compared to investigate quantitative differences in etiological influences on psychopathology between those with and without DLD. The genetic correlation between DLD and internalizing problems in childhood was significant, suggesting that their co-occurrence is due to common genetic influences. Similar, but nonsignificant effects were observed for externalizing problems. In addition, genetic influences on internalizing problems, but not externalizing problems, appeared to be higher in young people with DLD than those without DLD, suggesting that the presence of DLD may exacerbate genetic risk for internalizing problems. These findings indicate that genetic influences on internalizing problems may also confer susceptibility to DLD (or vice versa) and that DLD serves as an additional risk factor for those with a genetic predisposition for internalizing problems.

摘要

在患有发育性语言障碍(DLD)的年轻人中,心理健康问题的严重程度存在相当大的差异。导致这些个体差异的原因尚不清楚。在当前的文章中,使用来自 Twin Early Development Study 的数据,调查了患有 DLD(=325 人)和没有 DLD(=865 人)的儿童和青少年的精神病理学的遗传和环境影响。采用三变量模型来研究对 DLD 和精神病理学的病因影响,并拟合双变量异质性和同质性模型,以调查患有和不患有 DLD 的个体在精神病理学病因影响方面的定量差异。DLD 与儿童期内化问题之间的遗传相关性具有显著意义,表明它们的同时发生是由于共同的遗传影响。对外化问题也观察到类似但无统计学意义的影响。此外,遗传对内化问题的影响,而不是对外化问题的影响,在患有 DLD 的年轻人中似乎高于没有 DLD 的年轻人,这表明 DLD 的存在可能会加剧内化问题的遗传风险。这些发现表明,遗传对内化问题的影响也可能导致 DLD(或反之亦然)的易感性,并且 DLD 是那些具有内化问题遗传倾向的人的额外风险因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a251/8996291/cacadabe725c/10.1177_00222194211019961-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a251/8996291/cacadabe725c/10.1177_00222194211019961-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a251/8996291/cacadabe725c/10.1177_00222194211019961-fig1.jpg

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