Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Pediatr Rheumatol Online J. 2021 Jun 10;19(1):88. doi: 10.1186/s12969-021-00577-3.
To explore possible anti-inflammatory effects of the specific carbohydrate diet in children with juvenile idiopathic arthritis. This diet has shown anti-inflammatory effect in children with inflammatory bowel disease.
Twenty-two patients with juvenile idiopathic arthritis (age 6.3-17.3 years), with ≤2 inflamed joints and an erythrocyte sedimentation rate < 30 mm/h, were included in this explorative study. Fifteen children completing four weeks on the diet were evaluated. A dietician introduced parents and children to the diet, and two follow-ups were performed during the intervention. Conventional laboratory tests and multiplex analyses of 92 inflammatory proteins were used. Short-chain fatty acids in faecal samples were examined.
The diet significantly decreased morning stiffness (p = 0.003) and pain (p = 0.048). Physical function, assessed through the child health assessment questionnaire, improved (p = 0.022). Arthritis improved in five of the seven children with arthritis; in those seven, multiplex analyses showed a significant decrease in nine inflammatory proteins, including TNF-alpha (p = 0.028), after four weeks. Faecal butyrate, analysed in all 15 participants, increased significantly (p = 0.020).
The specific carbohydrate diet may have significant positive effects on arthritis in children with juvenile idiopathic arthritis, but further studies are needed.
NCT04205500 , 2019/12/17, retrospectively registered. URL: https://register.clinicaltrials.gov.
探索特定碳水化合物饮食在幼年特发性关节炎儿童中的可能抗炎作用。这种饮食已在炎症性肠病儿童中显示出抗炎作用。
本探索性研究纳入了 22 名患有幼年特发性关节炎的儿童（年龄 6.3-17.3 岁），他们的炎症关节数≤2 且红细胞沉降率<30mm/h。15 名完成四周饮食的儿童接受了评估。营养师向父母和儿童介绍了饮食，在干预期间进行了两次随访。常规实验室检查和 92 种炎症蛋白的多重分析用于评估。还检查了粪便样本中的短链脂肪酸。
该饮食显著降低了晨僵（p=0.003）和疼痛（p=0.048）。通过儿童健康评估问卷评估的身体功能得到改善（p=0.022）。在 7 名患有关节炎的儿童中，有 5 名儿童的关节炎得到改善；在这 7 名儿童中，经过四周后，多重分析显示 9 种炎症蛋白中的 TNF-α显著降低（p=0.028）。所有 15 名参与者的粪便丁酸盐分析均显著增加（p=0.020）。
特定碳水化合物饮食可能对幼年特发性关节炎儿童的关节炎有显著的积极影响，但需要进一步的研究。
NCT04205500 ，2019 年 12 月 17 日，回顾性注册。网址：https://register.clinicaltrials.gov。
