Langer Agnes, Hasenauer Sebastian, Flotz Anna, Gassner Lucia, Pokan Rochus, Dabnichki Peter, Wizany Laurenz, Gruber Jakob, Roth Dominik, Zimmel Sarah, Treven Marco, Schmoeger Michaela, Willinger Ulrike, Maetzler Walter, Zach Heidemarie
Department of Neurology, Medical University of Vienna, Vienna, Austria.
School of Engineering, RMIT University, Melbourne, VIC, Australia.
NPJ Parkinsons Dis. 2021 Jun 10;7(1):49. doi: 10.1038/s41531-021-00193-8.
Physical activity is of prime importance in non-pharmacological Parkinson's disease (PD) treatment. The current study examines the effectiveness and feasibility of sport climbing in PD patients in a single-centre, randomised controlled, semi-blind trial. A total of 48 PD patients without experience in climbing (average age 64 ± 8 years, Hoehn & Yahr stage 2-3) were assigned either to participate in a 12-week sport climbing course (SC) or to attend an unsupervised physical training group (UT). The primary outcome was the improvement of symptoms on the Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale part III (MDS-UPDRS-III). Sport climbing was associated with a significant reduction of the MDS-UPDRS-III (-12.9 points; 95% CI -15.9 to -9.8), while no significant improvement was to be found in the UT (-3.0 points; 95% CI -6.0 to 0.1). Bradykinesia, rigidity and tremor subscales significantly improved in SC, but not in the unsupervised control group. In terms of feasibility, the study showed a 99% adherence of participants to climbing sessions and a drop-out rate of only 8%. No adverse events occurred. This trial provides class III evidence that sport climbing is highly effective and feasible in mildly to moderately affected PD patients.
体育活动在帕金森病（PD）的非药物治疗中至关重要。本研究在一项单中心、随机对照、半盲试验中，考察了攀岩运动对PD患者的有效性和可行性。共有48名无攀岩经验的PD患者（平均年龄64±8岁，Hoehn & Yahr分期为2 - 3期）被分配到参加为期12周的攀岩课程（SC）组或参加无监督体育训练组（UT）。主要结局指标是帕金森病统一评分量表第三部分（MDS - UPDRS - III）的症状改善情况。攀岩运动与MDS - UPDRS - III评分显著降低相关（-12.9分；95%置信区间-15.9至-9.8），而在无监督训练组未发现显著改善（-3.0分；95%置信区间-6.0至0.1）。运动迟缓、强直和震颤分量表在攀岩组有显著改善，但在无监督对照组未改善。在可行性方面，该研究显示参与者对攀岩课程的依从率为99%，脱落率仅为8%。未发生不良事件。本试验提供了III级证据，表明攀岩运动对轻度至中度受影响的PD患者非常有效且可行。
