Immunology Department, Nîmes University Hospital, Place du Pr Debré, 30029, Nîmes, France.
Institute of Human Genetics, CNRS-Montpellier University UMR9002, 141 rue de la Cardonille, 34396, Montpellier Cedex 5, France.
Sci Rep. 2021 Jun 10;11(1):12314. doi: 10.1038/s41598-021-91758-3.
We tested the hypothesis that a particular immune activation profile might be correlated with insulin resistance in a general population. By measuring 43 markers of immune, endothelial, and coagulation activation, we have previously shown that five different immune activation profiles may be distinguished in 150 volunteers. One of these profiles, Profile 2, characterized by CD4+ T cell senescence, inflammation, monocyte, B cell, and endothelial activation, presented elevated insulinemia, glycemia, triglyceridemia, and γ-glutamyl transferase, a marker of liver injury, in comparison with other profiles. Our data are compatible with a model in which a particular immune activation profile might favor the development of insulin resistance and metabolic syndrome. In this hypothesis, identification of this profile, that is feasible with only 3 markers with an error rate of 5%, might allow to personalize the screening and prevention of metabolic syndrome-driven morbidities as liver steatosis.
我们检验了一个假设，即在一般人群中，特定的免疫激活特征可能与胰岛素抵抗相关。通过测量 43 种免疫、内皮和凝血激活标志物，我们之前已经证明，在 150 名志愿者中可以区分出五种不同的免疫激活特征。这些特征之一，即特征 2，其特点是 CD4+T 细胞衰老、炎症、单核细胞、B 细胞和内皮激活，与其他特征相比，表现出升高的胰岛素血症、血糖、甘油三酯和γ-谷氨酰转移酶，这是肝损伤的标志物。我们的数据与这样一种模型相符，即特定的免疫激活特征可能有利于胰岛素抵抗和代谢综合征的发展。在这种假设中，通过仅使用 3 个标志物（错误率为 5%）来识别这种特征，可能能够个性化筛查和预防代谢综合征相关的疾病，如肝脂肪变性。
