Institute for Global Health, University College London, London, United Kingdom.
Amsterdam institute for Global Health and Development, Amsterdam, Netherlands.
Front Immunol. 2020 Oct 6;11:581616. doi: 10.3389/fimmu.2020.581616. eCollection 2020.
People with HIV on successful antiretroviral therapy show signs of premature aging and are reported to have higher rates of age-associated comorbidities. HIV-associated immune dysfunction and inflammation have been suggested to contribute to this age advancement and increased risk of comorbidities.
Partial least squares regression (PLSR) was used to explore associations between biological age advancement and immunological changes in the T cell and monocyte compartment in people with HIV (n=40), comparable HIV-negative individuals (n=40) participating in the Comorbidity in Relation to AIDS (COBRA) cohort, and blood donors (n=35).
We observed that age advancement in all three groups combined was associated with a monocyte immune phenotypic profile related to inflammation and a T cell immune phenotypic associated with immune senescence and chronic antigen exposure. Interestingly, a unique monocyte and T cell immune phenotypic profile predictive for age advancement was found within each group. An inflammatory monocyte immune phenotypic profile associated with age advancement in HIV-negative individuals, while the monocyte profile in blood donors and people with HIV was more reflective of loss of function. The T cell immune phenotypic profile in blood donors was related to loss of T cell function, whereas the same set of markers were related to chronic antigen stimulation and immune senescence in HIV-negative individuals. In people with HIV, age advancement was related to changes in the CD4 T cell compartment and more reflective of immune recovery after cART treatment.
The identified monocyte and T cell immune phenotypic profiles that were associated with age advancement, were strongly related to inflammation, chronic antigen exposure and immune senescence. While the monocyte and T cell immune phenotypic profile within the HIV-negative individuals reflected those observed in the combined three groups, a distinct profile related to immune dysfunction, was observed within blood donors and people with HIV. These data suggest that varying exposures to lifestyle and infection-related factors may be associated with specific changes in the innate and adaptive immune system, that all contribute to age advancement.
成功接受抗逆转录病毒治疗的艾滋病毒感染者表现出早衰迹象，并报告称其年龄相关合并症的发病率更高。艾滋病毒相关的免疫功能障碍和炎症被认为是导致这种年龄提前和合并症风险增加的原因。
偏最小二乘回归（PLSR）用于探索艾滋病毒感染者（n=40）、可比艾滋病毒阴性个体（n=40）和献血者（n=35）中 T 细胞和单核细胞区室的免疫变化与生物学年龄进展之间的关联。COBRA 队列）。
我们观察到，所有三组年龄的进展都与单核细胞免疫表型特征相关，该特征与炎症有关，而 T 细胞免疫表型特征与免疫衰老和慢性抗原暴露有关。有趣的是，在每个组中都发现了一个独特的单核细胞和 T 细胞免疫表型特征，可以预测年龄的进展。与艾滋病毒阴性个体年龄进展相关的炎症性单核细胞免疫表型特征，而献血者和艾滋病毒感染者的单核细胞谱更能反映功能丧失。献血者的 T 细胞免疫表型特征与 T 细胞功能丧失有关，而相同的一组标志物与艾滋病毒阴性个体的慢性抗原刺激和免疫衰老有关。在艾滋病毒感染者中，年龄的进展与 CD4 T 细胞区室的变化有关，这更能反映 cART 治疗后的免疫恢复。
与年龄进展相关的鉴定出的单核细胞和 T 细胞免疫表型特征与炎症、慢性抗原暴露和免疫衰老密切相关。虽然艾滋病毒阴性个体中的单核细胞和 T 细胞免疫表型特征反映了三组中观察到的特征，但在献血者和艾滋病毒感染者中观察到了与免疫功能障碍相关的独特特征。这些数据表明，不同的生活方式和感染相关因素的暴露可能与固有和适应性免疫系统的特定变化有关，这些变化都导致了年龄的增长。
Zotero 插件
