全取代共轭苯并呋喃核心：多炔串联偶联与环丙烯酮的氧化
Fully Substituted Conjugate Benzofuran Core: Multiyne Cascade Coupling and Oxidation of Cyclopropenone.
作者信息
Yao Liangliang, Hu Qiong, Bao Li, Zhu Wenjing, Hu Yimin
机构信息
Key Laboratory of Functional Molecular Solids, Ministry of Education; Anhui Laboratory of Molecule-Based Materials, State Laboratory Cultivation Base, College of Chemistry and Materials Science, Anhui Normal University, Wuhu, Anhui 241002, China.
出版信息
Org Lett. 2021 Jul 2;23(13):4971-4975. doi: 10.1021/acs.orglett.1c01304. Epub 2021 Jun 11.
An unprecedented C═C double bond cleavage of cyclopropenone and dioxygen activation by multiyne cascade coupling has been developed. This chemistry provides a novel, simple, and efficient approach to synthesize fully substituted conjugate benzofuran derivatives from simple substrates under mild conditions. The density functional theory (DFT) calculations reveal that the unique homolytic cleavages of cyclopropenone and molecular oxygen are crucial to the success of this reaction.
通过多炔串联偶联实现了环丙烯酮前所未有的C═C双键裂解和双氧活化。这种化学方法提供了一种新颖、简单且高效的途径，可在温和条件下从简单底物合成完全取代的共轭苯并呋喃衍生物。密度泛函理论（DFT）计算表明，环丙烯酮和分子氧独特的均裂对该反应的成功至关重要。
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