Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering , South China University of Technology , Guangzhou 510640 , P. R. China.
Org Lett. 2018 Aug 3;20(15):4434-4438. doi: 10.1021/acs.orglett.8b01718. Epub 2018 Jul 20.
An unprecedented Zn-promoted selective cleavage of vinyl azides for the synthesis of 4-substituted quinolines is developed. In this conversion, vinyl azides function as a dual synthon via C═C and C-N bond cleavage with two C═C bonds and one C═N bond formation in a one-step manner. The reaction is appreciated for its readily accessible substrates, high step economy, mild conditions, and use of air as the sole oxidant.
发展了一种前所未有的 Zn 促进的 vinyl azides 的选择性断裂反应，用于合成 4-取代喹啉。在这个转化过程中，vinyl azides 通过 C═C 和 C-N 键的断裂，以及两个 C═C 键和一个 C═N 键的一步形成，作为一个双合成子发挥作用。该反应具有底物易得、步骤经济性高、反应条件温和以及仅使用空气作为唯一氧化剂等优点。
