Cullingford T E, Pollard J W
MRC Group in Human Genetic Diseases, Department of Biochemistry, King's College, Campden Hill, London, U.K.
J Reprod Fertil. 1988 Jul;83(2):909-14. doi: 10.1530/jrf.0.0830909.
The antiprogestagen RU 486 completely inhibited the progesterone-induced switch in cell proliferation from the luminal and glandular epithelia to the stroma in response to oestradiol-17 beta. It also inhibited the progesterone-induced differentiation of the uterine epithelium. Since the proliferative switch of the uterus and the differentiation of the epithelium are prerequisites for implantation, these inhibitory actions may, in part, explain the ability of RU 486 to prevent implantation. Furthermore, it also suggests that the proliferative response to oestradiol in the presence of progesterone may be a sensitive assay for compounds with anti-progestational activity.
抗孕激素RU 486完全抑制了孕酮诱导的在17β-雌二醇作用下细胞增殖从腔上皮和腺上皮向基质的转变。它还抑制了孕酮诱导的子宫上皮分化。由于子宫的增殖转变和上皮分化是着床的先决条件，这些抑制作用可能在一定程度上解释了RU 486防止着床的能力。此外，这也表明在孕酮存在下对雌二醇的增殖反应可能是一种检测具有抗孕激素活性化合物的灵敏方法。
