Cheng S V, Pollard J W
FEBS Lett. 1986 Feb 17;196(2):309-14. doi: 10.1016/0014-5793(86)80269-1.
Oestradiol-17 beta (E2) treatment of the ovariectomized mouse results in a synchronised wave of cell proliferation in the uterine luminal epithelium. At the peak of DNA synthesis the mRNA level of the c-rasH proto-oncogene and ornithine decarboxylase were significantly increased. Progesterone treatment completely inhibits the E2 induced wave of DNA synthesis but does not greatly influence the level of these 2 mRNAs. Thus in the uterine luminal epithelium E2 regulates the level of ornithine decarboxylase and c-rasH independently of cell proliferation.
用17β-雌二醇（E2）处理去卵巢小鼠，可导致子宫腔上皮细胞增殖同步化。在DNA合成高峰期，原癌基因c-rasH和鸟氨酸脱羧酶的mRNA水平显著升高。孕酮处理可完全抑制E2诱导的DNA合成波，但对这两种mRNA的水平影响不大。因此，在子宫腔上皮中，E2独立于细胞增殖调节鸟氨酸脱羧酶和c-rasH的水平。
